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【medical-news】国立卫生研究院奖给脊椎基底动脉供血不足研究小组和梅奥

NIH Awards VBI, Mayo Clinic $2.4M To Study Chronic Rhinosinusitis

Main Category: Ear, Nose and Throat News

Article Date: 12 May 2007 - 23:00 PDT

Virginia Bioinformatics Institute and Virginia Tech biological sciences associate professor Chris Lawrence is teaming up with Mayo Clinic on a $2.4 million project funded by the National Institute of Allergy and Infectious Diseases (NIAID). The work could help researchers develop treatments, diagnostic tools, and preventative measures for patients suffering from chronic rhinosinusitis (CRS).

CRS is a debilitating chronic airway disease that results in up to 18 - 22 million clinical cases per year and at least 30 million courses of antibiotic treatment (National Center for Health Statistics). CRS can produce inflammation of the lining of the nasal sinus. In some cases, this is followed by thickening of sinus mucosa and the formation of polyps or growths in the nasal cavity. Even with aggressive medical and surgical therapies, a significant number of patients with CRS have persistent or recurrent problems associated with the disease. The goal of the five-year project, entitled "The Pathogenesis of Chronic Rhinosinusitis," is to positively impact treatment, clinical decisions, and medical care costs involving CRS, as well as develop a better understanding of the mechanisms of the disease.

Dr. Chris Lawrence, associate professor at VBI, stated: "Several years ago researchers at Mayo, including clinical assistant professor Jens Ponikau, who is now at the University at Buffalo School of Medicine & Biomedical Sciences, and Hirohito Kita, professor of Immunology and the director of the Allergic Diseases Laboratory at Mayo, discovered that lymphocytes including T-cells from a significant percentage of CRS patients have an overzealous inflammatory immune response to antigens derived from common airborne fungi. The most exaggerated and statistically significant response by far was to Alternaria alternata antigens. Our research group along with VBI professor Brett Tyler has been sequencing the Alternaria brassicicola genome in collaboration with Washington University School of Medicine and developing functional genomics technologies for Alternaria research. It made sense to use the A. brassicicola genome resources, our bioinformatics infrastructure, and our molecular techniques to aid in the identification of the fungal products from the closely related species A. alternata that trigger the response in CRS patients. Since then, we have also started to amass genome data from A. alternata. The Mayo group had already performed a lot of work to characterize the fungal-associated immune responses in CRS patients. However, identifying the specific fungal antigens and other proteins contributing to the pathology of the disorder has proved elusive."

The new project will involve a transdisciplinary team of immunologists, allergy physicians, otorhinolaryngology surgeons, and genomic scientists.
NIH Awards VBI, Mayo Clinic $2.4M To Study Chronic Rhinosinusitis
国立卫生研究院奖给脊椎基底动脉供血不足研究小组和梅奥诊所两百四十万美元用于研究慢性鼻窦炎

Main Category: Ear, Nose and Throat News
主要类别:耳鼻咽喉新闻
Article Date: 12 May 2007 - 23:00 PDT
文章出版日期:2007年5月12日23点

Virginia Bioinformatics Institute and Virginia Tech biological sciences associate professor Chris Lawrence is teaming up with Mayo Clinic on a $2.4 million project funded by the National Institute of Allergy and Infectious Diseases (NIAID).
弗吉尼亚生物信息学院和弗吉尼亚生命科学技术学会的克理斯劳伦斯教授目前正在与梅奥诊所合作一个研究项目,该项目是由国家变态反应和感染性疾病协会资助的,资助的金额高达两百四十万美元。
The work could help researchers develop treatments, diagnostic tools, and preventative measures for patients suffering from chronic rhinosinusitis (CRS).
这项研究将帮助研究人员改进对慢性鼻窦炎患者治疗、诊断的工具以及预防慢性鼻窦炎的措施。

CRS is a debilitating chronic airway disease that results in up to 18 - 22 million clinical cases per year and at least 30 million courses of antibiotic treatment (National Center for Health Statistics).
慢性鼻窦炎是一种使人虚弱的呼吸道疾病。据全国健康状况统计中心统计报道:慢性鼻窦炎每年导致高达一千八百万到两千二百万例的临床病例的发生,并且至少有三百万病例接受了抗生素治疗。
CRS can produce inflammation of the lining of the nasal sinus. In some cases, this is followed by thickening of sinus mucosa and the formation of polyps or growths in the nasal cavity.
慢性鼻窦炎可以产生鼻窦腔内的炎症。在一些病例中,鼻窦腔粘膜增厚、息肉形成或在鼻腔内生长可以导致这种继发的鼻窦腔内的炎症。
Even with aggressive medical and surgical therapies, a significant number of patients with CRS have persistent or recurrent problems associated with the disease. The goal of the five-year project, entitled "The Pathogenesis of Chronic Rhinosinusitis," is to positively impact treatment, clinical decisions, and medical care costs involving CRS, as well as develop a better understanding of the mechanisms of the disease.

对于一些顽固性的慢性鼻窦炎病例,甚至采用侵入性治疗和外科治疗。但是仍有相当数量的慢性鼻窦炎患者在治疗后持续存在慢性鼻窦炎的症状或者出现再次复发的情况。这项为期五年的研究项目的研究目标就是以“慢性鼻窦炎的发病机理”为标题的,该目标包括积极的冲击治疗、临床决策、和慢性鼻窦炎的相关医疗费用,并且进一步更好的了解慢性鼻窦炎的疾病机制。

Dr. Chris Lawrence, associate professor at VBI, stated: "Several years ago researchers at Mayo, including clinical assistant professor Jens Ponikau, who is now at the University at Buffalo School of Medicine & Biomedical Sciences, and Hirohito Kita, professor of Immunology and the director of the Allergic Diseases Laboratory at Mayo, discovered that lymphocytes including T-cells from a significant percentage of CRS patients have an overzealous inflammatory immune response to antigens derived from common airborne fungi.
克理斯劳伦斯博士是脊椎基底动脉供血不足研究协会的副教授。他说:“几年前梅奥诊所的研究人员包括Jens Ponikau教授助理和免疫学教授Hirohito Kita。Jens Ponikau教授助理现在在巴福乐医学和生物医学科学大学。而Hirohito Kita教授同时也是梅奥诊所变态反应性疾病实验室的主任。他发现普通空气播散的霉菌衍生的抗原能引起慢性鼻窦炎患者过激的炎症免疫应答反应,而这些慢性鼻窦炎患者体内的淋巴细胞(包括T淋巴细胞)百分比有显著的升高。
The most exaggerated and statistically significant response by far was to Alternaria alternata antigens. Our research group along with VBI professor Brett Tyler has been sequencing the Alternaria brassicicola genome in collaboration with Washington University School of Medicine and developing functional genomics technologies for Alternaria research.
最言过其实的是对链格孢抗原的反应非常明显,具有统计学显著差异。我们的研究小组和脊椎基底动脉供血不足研究小组的Brett Tyler教授曾与华盛顿医科大学继续了格链孢酶甘蓝格链孢菌素基因组的后续研究,并且展开功能基因组科学技术对格链孢酶进行研究。
It made sense to use the A. brassicicola genome resources, our bioinformatics infrastructure, and our molecular techniques to aid in the identification of the fungal products from the closely related species A. alternata that trigger the response in CRS patients. Since then, we have also started to amass genome data from A. alternata.
这对运用甘蓝格链孢菌素A基因组资源、我们的生物信息基础和我们帮助确定霉菌产物的分子技术非常有意义。这种霉菌产物与甘蓝格链孢菌素A的种类非常接近,并且它能触发慢性鼻窦炎患者的反应。从那以后,我们又收集了大量有关甘蓝格链孢菌素A基因组的资料。
The Mayo group had already performed a lot of work to characterize the fungal-associated immune responses in CRS patients. However, identifying the specific fungal antigens and other proteins contributing to the pathology of the disorder has proved elusive."
梅奥小组已经完成了关于慢性鼻窦炎患者霉菌相关的免疫反应表现特征的大部分研究工作。然而,确定这种特殊的霉菌抗原和其它促使该疾病障碍发生的蛋白质还有待进一步的深入研究。”
The new project will involve a transdisciplinary team of immunologists, allergy physicians, otorhinolaryngology surgeons, and genomic scientists.这个新项目将需要一个由免疫学家、变态反应医师、耳鼻咽喉外科医师和基因组科学家组成的跨学科的研究团队。
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国立卫生研究院奖给脊椎基底动脉供血不足研究小组和梅奥诊所两百四十万美元用于研究慢性鼻窦炎

主要类别:耳鼻咽喉新闻

文章出版日期:2007年5月12日23点

弗吉尼亚生物信息学院和弗吉尼亚生命科学技术学会的克理斯劳伦斯教授目前正在与梅奥诊所合作一个研究项目,该项目是由国家变态反应和感染性疾病协会资助的,资助的金额高达两百四十万美元。这项研究将帮助研究人员改进对慢性鼻窦炎患者治疗、诊断的工具以及预防慢性鼻窦炎的措施。

慢性鼻窦炎是一种使人虚弱的呼吸道疾病。据全国健康状况统计中心统计报道:慢性鼻窦炎每年导致高达一千八百万到两千二百万例的临床病例的发生,并且至少有三百万病例接受了抗生素治疗。慢性鼻窦炎可以产生鼻窦腔内的炎症。在一些病例中,鼻窦腔粘膜增厚、息肉形成或在鼻腔内生长可以导致这种继发的鼻窦腔内的炎症。对于一些顽固性的慢性鼻窦炎病例,甚至采用侵入性治疗和外科治疗。但是仍有相当数量的慢性鼻窦炎患者在治疗后持续存在慢性鼻窦炎的症状或者出现再次复发的情况。这项为期五年的研究项目的研究目标就是以“慢性鼻窦炎的发病机理”为标题的,该目标包括积极的冲击治疗、临床决策、和慢性鼻窦炎的相关医疗费用,并且进一步更好的了解慢性鼻窦炎的疾病机制。

克理斯劳伦斯博士是脊椎基底动脉供血不足研究协会的副教授。他说:“几年前梅奥诊所的研究人员包括Jens Ponikau教授助理和免疫学教授Hirohito Kita。Jens Ponikau教授助理现在在巴福乐医学和生物医学科学大学。而Hirohito Kita教授同时也是梅奥诊所变态反应性疾病实验室的主任。他发现普通空气播散的霉菌衍生的抗原能引起慢性鼻窦炎患者过激的炎症免疫应答反应,而这些慢性鼻窦炎患者体内的淋巴细胞(包括T淋巴细胞)百分比有显著的升高。最言过其实的是对链格孢抗原的反应非常明显,具有统计学显著差异。我们的研究小组和脊椎基底动脉供血不足研究小组的Brett Tyler教授曾与华盛顿医科大学继续了格链孢酶甘蓝格链孢菌素基因组的后续研究,并且展开功能基因组科学技术对格链孢酶进行研究。这对运用甘蓝格链孢菌素A基因组资源、我们的生物信息基础和我们帮助确定霉菌产物的分子技术非常有意义。这种霉菌产物与甘蓝格链孢菌素A的种类非常接近,并且它能触发慢性鼻窦炎患者的反应。从那以后,我们又收集了大量有关甘蓝格链孢菌素A基因组的资料。梅奥小组已经完成了关于慢性鼻窦炎患者霉菌相关的免疫反应表现特征的大部分研究工作。然而,确定这种特殊的霉菌抗原和其它促使该疾病障碍发生的蛋白质还有待进一步的深入研究。”
这个新项目将需要一个由免疫学家、变态反应医师、耳鼻咽喉外科医师和基因组科学家组成的跨学科的研究团队。
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