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Re:【科普】小鼠,脱发治疗的希望?

Do Mice Hold Hope For Hair Loss?
小鼠,脱发治疗的希望?

Lab Tests Show Wound Healing May Spur New Hair Follicles In Adult Mice
实验室试验表明,在成年小鼠上创伤愈合可能刺激新毛囊。

(WebMD) It may be possible to grow new hair follicles, according to scientists studying mice.
(WebMD)根据科学家试验小鼠(结果),长出新的毛囊是可能的

The scientists—who included George Cotsarelis, MD, associate professor of dermatology at the University of Pennsylvania—report their findings in Nature.
包括Cotsarelis博士宾夕法尼亚州大学皮肤科病学副教授等科学家在《自然》上报告了他们的发现。

They noticed that in lab tests, adult mice grew new hair follicles in skin healing from wounds.
他们注意到在实验室的试验中,成年的小鼠在皮肤从创伤愈合时,长出了新的毛囊

Cotsarelis and colleagues found that the mice's wound-healing process involved the release of proteins called wnts.
Cotsarelis和他的同事们发现 小鼠创伤愈合过程包括一种称为“wnts”的蛋白的释放。

Those proteins made mature skin cells that don't normally make hair during wound healing behave like embryonic skin cells, giving rise to new hair follicles.
那些蛋白使非正常的、成熟的皮肤细胞,在创伤愈合行为中长出毛发像胚胎的皮肤细胞, 生长出新的毛囊。

"We showed that wound healing triggered an embryonic state in the skin which made it receptive to receiving instructions from wnt proteins," Cotsarelis says in a University of Pennsylvania news release.
“我们展示了在皮肤上创伤愈合触动了一种胚胎样的状态,使皮肤敏锐的接受了来自于“wnts”的蛋白的指令。” Cotsarelis在宾夕法尼亚州大学的新闻稿中说。

The researchers note that the wound-healing process may be a window of opportunity for mammals to generate new hair follicles via wnt proteins.
研究者主要到创伤愈合过程可能是一个哺乳动物通过“wnts”蛋白生长出新的毛囊的机会的窗户。

If so, that process might inspire new treatments for hair loss, wounds, and other degenerative skin disorders, write the researchers.
“假如这样,该过程可能启示脱发、创伤和其他的退化的皮肤疾病新的治疗。”研究者写道。

"We've found that we can influe[/color]nce wound healing with wnts or other proteins that allow the skin to heal in a way that has less scarring and includes all the normal structures of the skin, such as hair follicles and oil glands, rather than just a scar," says Cotsarelis in the news release.
[color=green]“我们已将发现 我们能用WNTS蛋白,或者其他的蛋白来影响伤口愈合。是允许皮肤以一种较少的瘢痕形成和包括所有正常皮肤结构(比如毛囊和皮脂腺),而不仅仅是瘢痕的方式来愈合。” Cotsarelis在新闻稿中说。


The study didn't involve any tests on people.
该研究没有包含任何人体试验。

Cotsarelis and his University of Pennsylvania colleague, Mayumi Ito, PhD, are listed as inventors on a patent application related to new hair follicle creation, notes the University of Pennsylvania, which owns that patent.
Cotsarelis和他的大学同事们Ito博士在和新的毛囊发明相关的专利申请书上作为发明者列入。专利所有者宾西法尼亚大学说。

Cotsarelis also co-founded and has ties to a start-up company called Follica, which licensed the patent, states the University of Pennsylvania.
宾西法尼亚大学说,Cotsarelis也协同建立和已经任职于新兴的公司Follica,该公司得到该专利的许可。By Miranda Hitti
Hitti 撰文
Reviewed by Brunilda Nazario
Nazario 评述(审稿)

编译后: 约550字

小鼠,脱发治疗的希望?
WebMD报道,根据科学家试验小鼠(结果),长出新的毛囊是可能的。包括Cotsarelis博士宾夕法尼亚州大学皮肤科病学副教授等科学家在《自然》上报告了他们的发现。他们注意到在实验室的动物试验中,成年的小鼠在皮肤从创伤愈合时,长出了新的毛囊。Cotsarelis和他的同事们发现小鼠创伤愈合过程包括一种称为“wnts”的蛋白的释放。那些蛋白使非正常的、成熟的皮肤细胞,在创伤愈合行为中长出毛发像胚胎的皮肤细胞, 生长出新的毛囊。
Cotsarelis在宾夕法尼亚州大学的新闻稿中说,“我们展示了在皮肤上创伤愈合触动了一种胚胎样的状态,使皮肤敏锐的接受了来自于“wnts”的蛋白的指令。” 研究者主要到创伤愈合过程可能是一个哺乳动物通过“wnts”蛋白生长出新的毛囊的机会的窗户,假如这样,该过程可能启示脱发、创伤和其他的退化的皮肤疾病新的治疗。Cotsarelis在新闻稿同时中说,他们已将发现使其能用WNTS蛋白,或者其他的蛋白来影响伤口愈合,是允许皮肤以一种较少的瘢痕形成和包括所有正常皮肤结构(比如毛囊和皮脂腺),而不仅仅是瘢痕的方式来愈合。该研究没有包含任何人体试验。
专利所有者宾西法尼亚大学说,“Cotsarelis和他的大学同事们Ito博士在和新的毛囊发明相关的专利申请书上作为发明者列入。同时Cotsarelis也协同建立和已经任职于新兴的公司Follica,该公司得到该专利的许可。”
Hitti 撰文,Nazario 评述(审稿)

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