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Kidney Ailment Linked to Risk of Peripheral Artery Disease
肾脏疾患与周围动脉病风险有关
Screening test could help prevent surgery and amputations, study says
研究表明筛查可帮助预防外科手术或截肢
HealthDay
By Robert Preidt
Thursday, January 11, 2007
健康日报Robert Preidt 2007年1月11，星期四
THURSDAY, Jan. 11 (HealthDay News) -- People with chronic kidney disease have an increased risk of peripheral arterial disease (PAD), a condition that causes reduced blood flow in the legs and can lead to amputation. PAD is usually caused by atherosclerosis -- hardening of the arteries.
1月11日，星期四健康日报消息--慢性肾病患者患周围血管疾病风险增加(PAD)，PAD造成下肢血流减少并导致截肢手术，其多由动脉粥样硬化引起--动脉硬化。
"Recognition of this increased risk is important, because early detection of PAD through a simple screening test could identify high-risk patients and prevent PAD-related complications, such as leg revascularization surgery and amputation," Dr. Keattiyoat Wattanakit of the University of Minnesota, said in a prepared statement.
明尼苏达州大学Keattiyoat Wattanakit博士在一次精彩的报告中指出，“提高对这种风险的认识是很重要的，早期筛查可筛选出高危人群，并预防PAD相关并发症发生，如下肢血管置换或截肢等”。
Wattanakit was lead author of a study of more than 14,000 middle-aged adults who were followed for an average of 13 years. The participants were split into three groups: those with normal kidney function; those with mildly decreased kidney function; and those with stage 3 or stage 4 chronic kidney disease, which results in a gradual, irreversible loss of kidney function.
在一项跟踪观察14,000中年人13年之多的大型研究中，Wattanakit是发起者。参与对象被分成三组：肾功正常者、轻度异常者、渐进性不可逆肾功能损害的3或4期慢性肾病患者。Overall, 7.1 percent of the study volunteers developed PAD. People with chronic kidney disease had a much higher rate of PAD (22.8 percent) than those with normal kidney function (6.6 percent). After adjusting for multiple factors (such as age, race and sex), the study authors found that the rate of PAD was nearly two times higher in chronic kidney disease patients than in people with normal kidney function.
全部受试者中PAD发病率为7.1%。慢性肾病患者PAD发病率为22.8%，明显高于肾功正常者6.6%。校正多因素（年龄、种族、性别）后，发现慢性肾病患者PAD发病率是肾功正常者的2倍。
The findings are published in the February issue of the Journal of the American Society of Nephrology.
此结果发表在美国肾脏病学会杂志2月份期刊上。
A simple test that compares blood pressure in the arms and legs can be used to screen people for PAD. This type of screening is already recommended for many diabetes patients.
筛查PAD方法很简便，就是对比分析受检者上下肢动脉血压。这种筛查也被推荐应用在糖尿病患者的筛查上。
"Our findings similarly highlight and support development of a PAD screening strategy to identify CKD (chronic kidney disease) patients at high risk for PAD," Wattanakit and the other study authors concluded.
Wattanakit和其他几位发起者得出：我们的数据同样说明支持和推广PAD筛查的必要性，以便及早发现有PAD高危因素的慢性肾病患者。
编译：题目：肾脏疾患与周围动脉病风险有关
1月11日，星期四健康日报消息--慢性肾病患者患周围血管疾病风险增加(PAD)，PAD造成下肢血流减少并导致截肢手术，其多由动脉粥样硬化引起--动脉硬化。
明尼苏达州大学Keattiyoat Wattanakit博士在一次精彩的报告中指出，“提高对这种风险的认识是很重要的，早期筛查可筛选出高危人群，并预防PAD相关并发症发生，如下肢血管置换或截肢等”。
在一项跟踪观察14,000中年人13年之多的大型研究中，Wattanakit是发起者。参与对象被分成三组：肾功正常者、轻度异常者、渐进性不可逆肾功能损害的3或4期慢性肾病患者。
全部受试者中PAD发病率为7.1%。慢性肾病患者PAD发病率为22.8%，明显高于肾功正常者6.6%。校正多因素（年龄、种族、性别）后，发现慢性肾病患者PAD发病率是肾功正常者的2倍。
此结果发表在美国肾脏病学会杂志2月份期刊上。
筛查PAD方法很简便，就是对比分析受检者上下肢动脉血压。这种筛查也被推荐应用在糖尿病患者的筛查上。
Wattanakit和其他几位发起者得出：我们的数据同样说明支持和推广PAD筛查的必要性，以便及早发现有PAD高危因素的慢性肾病患者。
