Early transient visual acuity loss after LASIK due to steroid-induced elevation of intraocular pressure.
Frucht-Pery J, Landau D, Raiskup F, Orucov F, Strassman E, Blumenthal EZ, Solomon A.
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
PURPOSE: To report the clinical course of early transient reduction of uncorrected visual acuity (UCVA) after LASIK surgery resulting from steroid-induced elevation of intraocular pressure (IOP). METHODS: Twenty-nine eyes of 15 patients who received topical corticosteroids after uneventful myopic LASIK surgery and had a decrease in UCVA within the first 3 weeks were evaluated retrospectively. RESULTS: Intraocular pressure increased by 4 to 30 mmHg from preoperative to postoperative days 4 to 20. Twenty-seven of 29 eyes had a decrease in UCVA and/or best spectacle-corrected visual acuity (BSCVA). All eyes, except one, had edema without evidence of inflammation in the interface or the remainder of the cornea. Discontinuation of topical corticosteroids and application of anti-glaucoma medications resulted in a decrease of IOP to normal levels, reduction or disappearance of the edema, and recovery of BSCVA. CONCLUSIONS: Early onset steroid-induced elevation of IOP after LASIK may cause corneal edema and a sudden decrease in UCVA. Rapid diagnosis and treatment can control IOP and recover the visual loss.
PMID: 17385289 [PubMed - indexed for MEDLINE]
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Early transient visual acuity loss after LASIK due to steroid-induced elevation of intraocular pressure.
由激素导致的LASIK术后早期一过性视力下降
Frucht-Pery J, Landau D, Raiskup F, Orucov F, Strassman E, Blumenthal EZ, Solomon A.
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
PURPOSE: To report the clinical course of early transient reduction of uncorrected visual acuity (UCVA) after LASIK surgery resulting from steroid-induced elevation of intraocular pressure (IOP).
目的：报告由于激素引起的眼内压升高导致LASIK术术后裸眼视力一过性视力下降的临床过程。
METHODS: Twenty-nine eyes of 15 patients who received topical corticosteroids after uneventful myopic LASIK surgery and had a decrease in UCVA within the first 3 weeks were evaluated retrospectively.
方法：在无事故的近视LASIK手术术后共15例患者29只眼睛，接受局部使用激素，在术后3周内进行裸眼视力下降的回顾性评估。
RESULTS: Intraocular pressure increased by 4 to 30 mmHg from preoperative to postoperative days 4 to 20. Twenty-seven of 29 eyes had a decrease in UCVA and/or best spectacle-corrected visual acuity (BSCVA). All eyes, except one, had edema without evidence of inflammation in the interface or the remainder of the cornea. Discontinuation of topical corticosteroids and application of anti-glaucoma medications resulted in a decrease of IOP to normal levels, reduction or disappearance of the edema, and recovery of BSCVA.
结果：在术后4-20天内，术后眼内压较术前升高4-30mmHg，29只眼睛中有27只眼睛有裸眼视力下降和/或最佳矫正视力。除1只外其他的均有水肿，但是没有证据表明在表明在表明或者角质层的剩余部分存在炎症。局部停止使用激素且使用抗青光眼疗法导致眼内压下降至正常水平，水肿减轻或者消失，裸眼超常视力恢复正常。
CONCLUSIONS: Early onset steroid-induced elevation of IOP after LASIK may cause corneal edema and a sudden decrease in UCVA. Rapid diagnosis and treatment can control IOP and recover the visual loss.
结论：LASIK手术术后早期发生的激素诱导的眼内压升高可能导致角膜水肿和裸眼视力突然下降，快速诊断和治疗能控制眼内压并且使视力从下降中恢复。
编译后 ：约440字
LASIK手术术后一般使用激素1-3周，但是往往出现视力的一过性下降，原因不甚明朗。来自以色列的研究人员Frucht-Pery 和他的同事们注意到这一临床过程，并且进行了一项回顾性研究认为，使用激素可以导致LASIK术后早期一过性视力下降。研究人员分析了在无事故的近视LASIK手术术后共15例患者29只眼睛，术后常规接受局部使用激素，在术后3周内进行裸眼视力下降评估。结果发现在术后4-20天内，术后眼内压较术前升高4-30mmHg，29只眼睛中有27只眼睛有裸眼视力下降和/或最佳矫正视力的下降。除1只眼睛外其他的眼睛均有水肿，但是没有证据表明在其表明或者角质层的剩余部分存在炎症；当局部停止使用激素且使用抗青光眼疗法使眼内压下降至正常水平，水肿减轻或者消失，裸眼超常视力恢复正常。研究人员认为LASIK手术术后早期发生的激素诱导的眼内压升高可能导致角膜水肿和裸眼视力突然下降，而快速诊断和治疗能控制眼内压并且使视力从下降中恢复。该研究成果发表在最新一期的《折光手术杂志》上。
蓝色字体为校对后翻译及编译，个人观点不一定准确，仅供参考。
Early transient visual acuity loss after LASIK due to steroid-induced elevation of intraocular pressure.
由激素导致的LASIK术后早期一过性视力下降
应用皮质类固醇药物诱发眼内压增高导致LASIK术后早期一过性视力下降
Frucht-Pery J, Landau D, Raiskup F, Orucov F, Strassman E, Blumenthal EZ, Solomon A.
Department of Ophthalmology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
PURPOSE: To report the clinical course of early transient reduction of uncorrected visual acuity (UCVA) after LASIK surgery resulting from steroid-induced elevation of intraocular pressure (IOP).
目的：报告由于激素引起的眼内压升高导致LASIK术术后裸眼视力一过性视力下降的临床过程。
Frucht-Pery J, Landau D, Raiskup F, Orucov F, Strassman E, Blumenthal EZ, Solomon A.
以色列 耶路撒冷 Hadassah-Hebrew大学医学中心眼科。
目的：报告因皮质类固醇药物诱发眼内压升高导致LASIK术术后裸眼视力一过性下降的临床病程。
METHODS: Twenty-nine eyes of 15 patients who received topical corticosteroids after uneventful myopic LASIK surgery and had a decrease in UCVA within the first 3 weeks were evaluated retrospectively.
方法：在无事故的近视LASIK手术术后共15例患者29只眼睛，接受局部使用激素，在术后3周内进行裸眼视力下降的回顾性评估。
方法：对行LASIK手术、无手术并发症且术后局部应用皮质类固醇类药物后术后3周内裸眼视力下降的15例患者29只眼进行回顾性分析。
RESULTS: Intraocular pressure increased by 4 to 30 mmHg from preoperative to postoperative days 4 to 20. Twenty-seven of 29 eyes had a decrease in UCVA and/or best spectacle-corrected visual acuity (BSCVA). All eyes, except one, had edema without evidence of inflammation in the interface or the remainder of the cornea. Discontinuation of topical corticosteroids and application of anti-glaucoma medications resulted in a decrease of IOP to normal levels, reduction or disappearance of the edema, and recovery of BSCVA.
结果：在术后4-20天内，术后眼内压较术前升高4-30mmHg，29只眼睛中有27只眼睛有裸眼视力下降和/或裸眼超常视力。除1只外其他的均有水肿，但是没有证据表明在表明在表明或者角质层的剩余部分存在炎症。局部停止使用激素且使用抗青光眼疗法导致眼内压下降至正常水平，水肿减轻或者消失，裸眼超常视力恢复正常。
结果：在术后4-20天内，术后眼内压较术前升高4-30mmHg，29只眼中有27只眼有裸眼视力和/或最佳矫正视力下降。除1只眼外其它术眼角膜均有水肿，但没有证据证明在切削面或角膜基质层存在炎症发生炎症。停用局部皮质类固醇药物且应用抗青光眼药物使眼内压下降至正常水平，水肿减轻或者消失，最佳矫正视力恢复正常。
CONCLUSIONS: Early onset steroid-induced elevation of IOP after LASIK may cause corneal edema and a sudden decrease in UCVA. Rapid diagnosis and treatment can control IOP and recover the visual loss.
结论：LASIK手术术后早期发生的激素诱导的眼内压升高可能导致角膜水肿和裸眼视力突然下降，快速诊断和治疗能控制眼内压并且使视力从下降中恢复。
结论：LASIK术后早期发生的皮质类固醇类药物诱导的眼内压升高可能导致角膜水肿和裸眼视力突然下降，及时的诊断和治疗可以控制眼内压并且使视力得到恢复。
编译后 ：约440字
LASIK手术术后一般使用激素1-3周，但是往往出现视力的一过性下降，原因不甚明朗。来自以色列的研究人员Frucht-Pery 和他的同事们注意到这一临床过程，并且进行了一项回顾性研究认为，使用激素可以导致LASIK术后早期一过性视力下降。研究人员分析了在无事故的近视LASIK手术术后共15例患者29只眼睛，术后常规接受局部使用激素，在术后3周内进行裸眼视力下降评估。结果发现在术后4-20天内，术后眼内压较术前升高4-30mmHg，29只眼睛中有27只眼睛有裸眼视力下降和/或裸眼超常视力的下降。除1只眼睛外其他的眼睛均有水肿，但是没有证据表明在其表明或者角质层的剩余部分存在炎症；当局部停止使用激素且使用抗青光眼疗法使眼内压下降至正常水平，水肿减轻或者消失，裸眼超常视力恢复正常。研究人员认为LASIK手术术后早期发生的激素诱导的眼内压升高可能导致角膜水肿和裸眼视力突然下降，而快速诊断和治疗能控制眼内压并且使视力从下降中恢复。该研究成果发表在最新一期的《折光手术杂志》上。
应用皮质类固醇药物诱发眼内压增高导致LASIK术后早期一过性视力下降
Frucht-Pery J, Landau D, Raiskup F, Orucov F, Strassman E, Blumenthal EZ, Solomon A.
以色列 耶路撒冷 Hadassah-Hebrew大学医学中心眼科。
目的：报告因皮质类固醇药物诱发眼内压升高导致LASIK术术后裸眼视力一过性下降的临床病程。
方法：对行LASIK手术、无手术并发症且术后局部应用皮质类固醇类药物后术后3周内裸眼视力下降的15例患者29只眼进行回顾性分析。
结果：在术后4-20天内，术后眼内压较术前升高4-30mmHg，29只眼中有27只眼有裸眼视力和/或最佳矫正视力下降。除1只眼外其它术眼角膜均有水肿，但没有证据证明在切削面或角膜基质层存在炎症发生炎症。停用局部皮质类固醇药物且应用抗青光眼药物使眼内压下降至正常水平，水肿减轻或者消失，最佳矫正视力恢复正常。
结论：LASIK术后早期发生的皮质类固醇类药物诱导的眼内压升高可能导致角膜水肿和裸眼视力突然下降，及时的诊断和治疗可以控制眼内压并且使视力得到恢复。该研究成果发表在最新一期的《屈光手术杂志》。
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