Title：Molecularly Imprinted Solid-Phase Extraction of Diazepam and Its Metabolites from Hair Samples
Author： Marinah M. Ariffin, Eleanor I. Miller, Peter A. G. Cormack, and Robert A. Anderson
Resource: Analytical Chemistry, 2007，79 (1)： 256 -262.
Abstract： An anti-diazepam, molecularly imprinted polymer (MIP) has been synthesized and used to extract diazepam and other benzodiazepines from hair samples via a molecularly imprinted solid-phase extraction (MISPE) protocol. Optimum retention of diazepam on the MIP columns was achieved using an apolar solvent, and the binding capacity of the polymer toward diazepam was found to be 110 ng of diazepam/mg of polymer. The recovery of a 50 ng diazepam standard spiked into blank hair was 93%, with good precision (RSD = 1.5%). The LOD and LOQ of diazepam in spiked hair samples were 0.09 and 0.14 ng/mg, respectively. The MISPE method was demonstrated to be applicable to the analysis of diazepam metabolites and other benzodiazepine drugs, in addition to diazepam itself. The application of the extraction method to postmortem hair samples yielded results that were in good agreement with the corresponding ELISA data (from blood samples) and data arising from the analysis of the same blood samples using a validated in-house SPE-LC-MS-MS method.
PMID: 17194149
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Title：Molecularly Imprinted Solid-Phase Extraction of Diazepam and Its Metabolites from Hair Samples
题目：分子印迹固相萃取毛发样品中的地西泮及其代谢物
Author： Marinah M. Ariffin, Eleanor I. Miller, Peter A. G. Cormack, and Robert A. Anderson
作者：Marinah M. Ariffin, Eleanor I. Miller, Peter A. G. Cormack, and Robert A. Anderson
Resource: Analytical Chemistry, 2007，79 (1)： 256 -262.
来源：《分析化学》2007年79卷第1期256-262页
Abstract：
摘要：
An anti-diazepam, molecularly imprinted polymer (MIP) has been synthesized and used to extract diazepam and other benzodiazepines from hair samples via a molecularly imprinted solid-phase extraction (MISPE) protocol.
一种抗地西泮的分子印迹聚合物(MIP)已经合成，并将分子印迹固相萃取(MISPE)技术用于从毛发样品中提取地西泮（成分）和提取其他地西泮（药物)。
Optimum retention of diazepam on the MIP columns was achieved using an apolar solvent, and the binding capacity of the polymer toward diazepam was found to be 110 ng of diazepam/mg of polymer.
在分子印迹聚合物柱上，使用非极性溶剂后，地西泮的保留良好可以实现，并且发现地西泮聚合物的结合容量是110ng地西泮/毫克聚合物。
The recovery of a 50 ng diazepam standard spiked into blank hair was 93%, with good precision (RSD = 1.5%). The LOD and LOQ of diazepam in spiked hair samples were 0.09 and 0.14 ng/mg, respectively.
添加到空白头发中的50ng地西泮样品回收率是93%,且有好的精密度 (RSD为1.5%)。在添加的头发样品中地西泮检测限和定量限分别为0.09和0.14纳克/毫克。
The MISPE method was demonstrated to be applicable to the analysis of diazepam metabolites and other benzodiazepine drugs, in addition to diazepam itself.
分子印迹固相萃取方法（MISPE）被证明了可用于地西泮代谢物和其他苯二氮卓类药物的分析，但除地西泮外。
The application of the extraction method to postmortem hair samples yielded results that were in good agreement with the corresponding ELISA data (from blood samples) and data arising from the analysis of the same blood samples using a validated in-house SPE-LC-MS-MS method.
死后头发样本提取法的应用已取得了结果,该方法是与从血液样品中（得到的）相应ELISA数据和运用一种有效的内部 SPE-LC-MS-MS方法从相同的血液样品中分析（得到）的数据一致。
PMID: 17194149
红色字体翻译不清楚
已部分修改,感谢楼下ala的意见!
编辑一下~~
分子印迹固相萃取毛发样品中的地西泮及其代谢物
Marinah M等研究者报道说,一种抗地西泮的分子印迹聚合物(MIP)已经合成，并将分子印迹固相萃取(MISPE)技术用于从毛发样品中提取地西泮成分和提取其他地西泮药物。(Analytical Chemistry,2007年79卷第1期256-262页)
在分子印迹聚合物柱上，使用非极性溶剂后，地西泮的保留良好可以实现，并且发现地西泮聚合物的结合容量是110ng地西泮/毫克聚合物。 添加到空白头发中的50ng地西泮样品回收率是93%,且有好的精密度 (RSD为1.5%)。在添加的头发样品中地西泮检测限和定量限分别为0.09和0.14纳克/毫克。
分子印迹固相萃取方法（MISPE）被证明了可用于地西泮代谢物和其他苯二氮卓类药物的分析，除地西泮外。死后头发样本提取法的应用已取得了结果,该方法是与从血液样品中得到的相应ELISA数据和运用一种有效的内部 SPE-LC-MS-MS法从相同的血液样品中分析得到的数据是一致的。(丁香)
请按文摘类新闻编译格式编译。
已修改,请斑竹审批~~~
谢谢沉浮的眼泪!
以下几点供讨论:
1."used to extract diazepam and other benzodiazepines from hair samples via a molecularly imprinted solid-phase extraction (MISPE) protocol."试译成"并将分子印迹固相萃取(MISPE)技术用于从毛发样品中提取地西泮（成分）和其他地西泮类药物。"会不会好一点?
2."Optimum retention "译成"保留良好".
3."LOD and LOQ"译成"检测限和定量限".
4."in addition to diazepam itself"译成"除地西泮外".
5."in good agreement with"译成"与...一致".这样,最后一句的主要意思即"该方法结果与ELISA及SPE-LC-MS-MS所得结果一致".
