Vaccine Can Help Reduce Frequent Ear Infections In Children, Research Shows
Main Category: Ear, Nose and Throat News
Article Date: 10 Apr 2007 - 2:00 PDT
A vaccine has been shown to help reduce the number of infants and toddlers developing frequent ear infections, according to new research from Katherine A. Poehling, M.D., a pediatrician at Brenner Children's Hospital, part of Wake Forest University Baptist Medical Center. Results from her study are published in the April issue of Pediatrics.
"This is exciting news for parents whose children suffer from frequent and painful ear infections," she said.
Poehling and a team of researchers followed about 27,000 children in New York and 150,000 children in Tennessee from birth to two years old who were born after the pneumococcal conjugate vaccine (PCV7) was licensed. The vaccine was approved to help protect children from potentially deadly strains of meningitis and other pneumococcal diseases such as ear infections.
Poehling found that, during the time that vaccine coverage increased, the number of vaccinated children who developed frequent ear infections and/or received ear tubes declined by 16 percent in Tennessee and 25 percent in New York.
"This vaccine has benefited both children and adults since being introduced into the vaccination schedule," Poehling said. "We have seen declines in the incidence of serious infections such as pneumococcal meningitis in both children and adults, as well as the number of children developing frequent ear infections."
The PCV7 vaccine was licensed by the FDA in 2000. The Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices recommended the vaccine be part of the routine vaccination schedule the same year. Children receive four doses of the vaccine: at age two months, four months, six months and again at about 12 to 15 months, Poehling said.
Ear infections are one of the most common infections in children. Before the vaccine was introduced into the vaccination schedule, about one-third of ear infections were caused by the pneumococcal bacteria.
"While most children have at least one ear infection by their second birthday, 25 to 30 percent of children will develop frequent ear infections, or about three or four each year," Poehling said.
Many of these children - about one of every 15 to 25 children -- will end up with ear tubes by the age of two, she said.
"Although these results are very exciting, we need to carefully monitor the trends in ear infections because pnuemococcal strains not included in the vaccine may increase and potentially diminish these gains," she said.
The PCV7 vaccine only protects against seven virulent strains of pneumococcal bacteria from 90 known strains.
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Poehling conducted the research during her tenure at Vanderbilt University Medical Center in Nashville, Tenn. Co-researchers included: Peter G. Szilagyi, M.D., and Richard D. Barth, from the University of Rochester School of Medicine in New York; J.Pekka Nuorti, M.D., and Stacey W. Martin, M.S., from the CDC; and Carlos G. Grijalva, M.D., M.P.H., Bonnie LaFleur, Ph.D., M.P.H., Ed Mitchel, M.S., and Marie R. Griffin, M.D., M.P.H., from Vanderbilt University School of Medicine.
The research was funded by the CDC and the Robert Wood Johnson Foundation.
Contact: Karen Richardson
Wake Forest University Baptist Medical Center
Vaccine Can Help Reduce Frequent Ear Infections In Children, Research Shows
研究表明：疫苗能帮助儿童减少频繁的耳部感染
Main Category: Ear, Nose and Throat News
主要类别：耳鼻喉新闻
Article Date: 10 Apr 2007 - 2:00 PDT
文章出版日期：2007年4月10日
A vaccine has been shown to help reduce the number of infants and toddlers developing frequent ear infections, according to new research from Katherine A. Poehling, M.D., a pediatrician at Brenner Children's Hospital, part of Wake Forest University Baptist Medical Center. Results from her study are published in the April issue of Pediatrics.
Brenner儿童医院是醒林大学浸信会教友医学中心的一个部门，而Katherine A. Poehling是Brenner儿童医院的一名小儿科医师。据她的最新研究报道：一种疫苗已经表现出奇特殊的作用，它能帮助婴儿和初学走路的孩子减少频繁发生耳部感染的数量。她的这项研究结果发表在《小儿科学杂志》的四月份的期刊上。
"This is exciting news for parents whose children suffer from frequent and painful ear infections," she said.
她说：“对于那些饱受频繁发作和痛苦不堪的耳部感染折磨的孩子们的父母们来说，这是个非常令人兴奋的新闻。”
Poehling and a team of researchers followed about 27,000 children in New York and 150,000 children in Tennessee from birth to two years old who were born after the pneumococcal conjugate vaccine (PCV7) was licensed. The vaccine was approved to help protect children from potentially deadly strains of meningitis and other pneumococcal diseases such as ear infections.
Poehling和一组研究人员追踪了约两万七千名纽约儿童和十五万名田纳西州儿童从出生到两周岁的相关情况。这些儿童均是在肺炎链球菌结合物疫苗得到许可批准使用之后出生的。
Poehling found that, during the time that vaccine coverage increased, the number of vaccinated children who developed frequent ear infections and/or received ear tubes declined by 16 percent in Tennessee and 25 percent in New York.
Poehling发现：随着疫苗接种覆盖范围的增加，接种过疫苗的孩子们发生频繁耳部感染和/或接受耳部置管的人数明显减少，在田纳西州和在纽约分别为16%和25%。
"This vaccine has benefited both children and adults since being introduced into the vaccination schedule," Poehling said. "We have seen declines in the incidence of serious infections such as pneumococcal meningitis in both children and adults, as well as the number of children developing frequent ear infections."
Poehling 说：“自从这种疫苗接种被引入计划日程以来，该疫苗已经使儿童和成人受益。我们已经观察到严重耳部感染发病率的下降，例如：儿童和成人患肺炎链球菌性脑脊膜炎发病率的下降以及儿童发生频繁耳部感染人数的减少。”
The PCV7 vaccine was licensed by the FDA in 2000. The Centers for Disease Control and Prevention's (CDC) Advisory Committee on Immunization Practices recommended the vaccine be part of the routine vaccination schedule the same year. Children receive four doses of the vaccine: at age two months, four months, six months and again at about 12 to 15 months, Poehling said.
食品与药物管理局在二零零零年为肺炎链球菌结合物疫苗批准了执照。疾病控制和预防中心免疫接种实施顾问委员会在同一年推荐这种疫苗为常规疫苗接种计划的一部分。Poehling说：孩子们将在出生后两个月、四个月、六个月和十二到十五个月左右接种四个剂量的疫苗。
Ear infections are one of the most common infections in children. Before the vaccine was introduced into the vaccination schedule, about one-third of ear infections were caused by the pneumococcal bacteria.
耳部感染是儿童最常见的感染性疾病之一。在该疫苗列入疫苗接种计划日程之前，大约有三分之一的耳部感染是由肺炎链球菌引起的。
"While most children have at least one ear infection by their second birthday, 25 to 30 percent of children will develop frequent ear infections, or about three or four each year," Poehling said.
Poehling说：“大多数的孩子到他们两周岁时至少已患有一次耳部感染，百分之二十五到百分之三十的孩子将发展成频繁耳部感染或者每年发作三到四次耳部感染。”
Many of these children - about one of every 15 to 25 children -- will end up with ear tubes by the age of two, she said.
她说：这些耳部感染的孩子中，约有十五分之一到二十五分之一的人到他们两岁时将最终以耳部置管而告终。
"Although these results are very exciting, we need to carefully monitor the trends in ear infections because pnuemococcal strains not included in the vaccine may increase and potentially diminish these gains," she said.
她说：“尽管这些结果令人非常兴奋，我们仍需要小心的监视耳部感染的发展动态，因为该疫苗并未包含肺炎球菌菌株将可能增加潜在的感染风险。”
The PCV7 vaccine only protects against seven virulent strains of pneumococcal bacteria from 90 known strains.
这种肺炎链球菌结合物疫苗仅预防和对抗九十种已知肺炎链球菌中的七种肺炎链球菌菌株强毒力菌株。
###
Poehling conducted the research during her tenure at Vanderbilt University Medical Center in Nashville, Tenn. Co-researchers included: Peter G. Szilagyi, M.D., and Richard D. Barth, from the University of Rochester School of Medicine in New York; J.Pekka Nuorti, M.D., and Stacey W. Martin, M.S., from the CDC; and Carlos G. Grijalva, M.D., M.P.H., Bonnie LaFleur, Ph.D., M.P.H., Ed Mitchel, M.S., and Marie R. Griffin, M.D., M.P.H., from Vanderbilt University School of Medicine.
Poehling在他在田纳西州范德比尔大学纳什维尔医学中心任教期间指导了这项研究。他的合作研究人员包括Peter G. Szilagyi医学博士、纽约罗彻斯特大学医学院的Richard D. Barth、J.Pekka Nuorti医学博士、来自传染病中心的Stacey W. Martin医学学士、Carlos G. Grijalva医学博士M.P.H.、Bonnie LaFleur哲学博士M.P.H.、Ed Mitchel医学学士和范德比尔大学医学院的Marie R. Griffin医学博士M.P.H.。
The research was funded by the CDC and the Robert Wood Johnson Foundation.
这些研究人员由传染病中心罗伯特乌德约翰生基金会提供资助资金。
Contact: Karen Richardson
联系人：Karen Richardson
Wake Forest University Baptist Medical Center
Wake Forest 大学Baptist 医学中心
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（1012字）
研究表明：疫苗能帮助儿童减少频繁的耳部感染
主要类别：耳鼻喉新闻
文章出版日期：2007年4月10日
Brenner儿童医院是醒林大学浸信会教友医学中心的一个部门，而Katherine A. Poehling是Brenner儿童医院的一名小儿科医师。据她的最新研究报道：一种疫苗已经表现出奇特殊的作用，它能帮助婴儿和初学走路的孩子减少频繁发生耳部感染的数量。她的这项研究结果发表在《小儿科学杂志》的四月份的期刊上。
她说：“对于那些饱受频繁发作和痛苦不堪的耳部感染折磨的孩子们的父母们来说，这是个非常令人兴奋的新闻。”
Poehling和一组研究人员追踪了约两万七千名纽约儿童和十五万名田纳西州儿童从出生到两周岁的相关情况。这些儿童均是在肺炎链球菌结合物疫苗得到许可批准使用之后出生的。
Poehling发现：随着疫苗接种覆盖范围的增加，接种过疫苗的孩子们发生频繁耳部感染和/或接受耳部置管的人数明显减少，在田纳西州和在纽约分别为16%和25%。
Poehling 说：“自从这种疫苗接种被引入计划日程以来，该疫苗已经使儿童和成人受益。我们已经观察到严重耳部感染发病率的下降，例如：儿童和成人患肺炎链球菌性脑脊膜炎发病率的下降以及儿童发生频繁耳部感染人数的减少。”
食品与药物管理局在二零零零年为肺炎链球菌结合物疫苗批准了执照。疾病控制和预防中心免疫接种实施顾问委员会在同一年推荐这种疫苗为常规疫苗接种计划的一部分。Poehling说：孩子们将在出生后两个月、四个月、六个月和十二到十五个月左右接种四个剂量的疫苗。
耳部感染是儿童最常见的感染性疾病之一。在该疫苗列入疫苗接种计划日程之前，大约有三分之一的耳部感染是由肺炎链球菌引起的。
Poehling说：“大多数的孩子到他们两周岁时至少已患有一次耳部感染，百分之二十五到百分之三十的孩子将发展成频繁耳部感染或者每年发作三到四次耳部感染。”
她说：这些耳部感染的孩子中，约有十五分之一到二十五分之一的人到他们两岁时将最终以耳部置管而告终。
她说：“尽管这些结果令人非常兴奋，我们仍需要小心的监视耳部感染的发展动态，因为该疫苗并未包含肺炎球菌菌株将可能增加潜在的感染风险。”
这种肺炎链球菌结合物疫苗仅预防和对抗九十种已知肺炎链球菌中的七种肺炎链球菌菌株强毒力菌株。
###
Poehling在他在田纳西州范德比尔大学纳什维尔医学中心任教期间指导了这项研究。他的合作研究人员包括Peter G. Szilagyi医学博士、纽约罗彻斯特大学医学院的Richard D. Barth、J.Pekka Nuorti医学博士、来自传染病中心的Stacey W. Martin医学学士、Carlos G. Grijalva医学博士M.P.H.、Bonnie LaFleur哲学博士M.P.H.、Ed Mitchel医学学士和范德比尔大学医学院的Marie R. Griffin医学博士M.P.H.。
这些研究人员由传染病中心罗伯特乌德约翰生基金会提供资助资金。
联系人：Karen Richardson
Wake Forest 大学Baptist 医学中心
