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【medical-news】抗癫痫药加巴喷丁能改善儿童易激惹状态

Anti-seizure drug calms irritable kids

Reuters Health
Thursday, February 22, 2007
By David Douglas

NEW YORK (Reuters Health) - Treatment with the anti-seizure drug gabapentin may improve the irritability seen in certain children with neurologic impairments, researchers report in the journal Pediatrics.

"Irritability may represent abnormal signaling of the...nervous system," lead investigator Dr. Julie M. Hauer told Reuters Health. The present study suggests pain in the gastrointestinal tract is "a plausible source of chronic irritability in neurologically impaired children."

Hauer, who is currently at Children's Hospital Boston, and colleagues point out that neurologically impaired children have higher than normal rates of chronic pain and irritability that persist in children despite thorough medical examination and treatment of possible pain sources. Parents commonly identify the gastrointestinal tract as a source of pain in these children.

The researchers conducted a review of the files of nine children who had been treated with gabapentin for recurrent disruptive irritability. None of the children could speak or walk and they often cried on a daily basis for an hour or longer.

After initiation of gabapentin therapy, the children appeared to be symptom-free for periods ranging from 3 months to 3 years.

For one child, the parents requested that treatment be halted, despite excellent symptom control, because of involuntary eye movements that arose with use of the drug. The symptoms returned within one week.

In another child, who had been successfully treated for 2 years, discontinuation of gabapentin also led to a recurrence of symptoms. The symptoms resolved when therapy was restarted.

For such children, Hauer concluded, the findings "suggest a trial of gabapentin when there is no identifiable source of pain despite comprehensive evaluation and management."

SOURCE: Pediatrics, February 2007.

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译者注:不知何故,我好像也认领了这篇文章,感觉有点意思,于是就翻了出来,结果一找原帖发现神农兄已经翻完了,但我也贴这儿吧,省得自己的功夫白费了,权当交流了。至于给不给加分,请版主定夺。本人绝菲有意为之。实乃译完后才发现的,不胜懊悔,但也不想就此浪费了自己的心血,所以还是贴出来吧。贻笑大方了......还请同仁批评指正。
Reuters Health
Thursday, February 22, 2007
By David Douglas
路透社健康专栏 2007-2-22 星期四 作者:大卫.道格拉斯
NEW YORK (Reuters Health) - Treatment with the anti-seizure drug gabapentin may improve the irritability seen in certain children with neurologic impairments, researchers report in the journal Pediatrics.
纽约(路透社健康专栏)— 研究人员在《儿科学杂志》报道,在某些有特定神经功能缺损的儿童身上应用抗癫痫药加巴喷丁可能会改善其易激惹的状态。
"Irritability may represent abnormal signaling of the...nervous system," lead investigator Dr. Julie M. Hauer told Reuters Health. The present study suggests pain in the gastrointestinal tract is "a plausible source of chronic irritability in neurologically impaired children."
易激惹状态或许表现了神经系统效能好传递的异常。研究领导者,Julie M. Hauer博士告诉路透社健康专栏,“目前的研究表明胃肠道的疼痛是一种颇似有神经缺损的儿童的慢性易激惹信号源。”
Hauer, who is currently at Children's Hospital Boston, and colleagues point out that neurologically impaired children have higher than normal rates of chronic pain and irritability that persist in children despite thorough medical examination and treatment of possible pain sources. Parents commonly identify the gastrointestinal tract as a source of pain in these children.
Hauer目前在波士顿儿童医院工作,他与同事研究后指出,神经学上有缺陷的儿童较正常儿童有更高的发生慢性疼痛和易激惹的发病率,而且尽管经过彻底的检查与治疗可能的疼痛根源后这种状况仍会持续。患儿家长通常认为胃肠道是这些儿童疼痛发生的根源。
The researchers conducted a review of the files of nine children who had been treated with gabapentin for recurrent disruptive irritability. None of the children could speak or walk and they often cried on a daily basis for an hour or longer.
研究者整理了涉及九个曾经接受过加巴喷丁用于治疗分裂性易激惹疾病的儿童的病例总综述。这些儿童中没有人能说话或步行并且他们经常一天哭泣至少一个小时甚至更长。
After initiation of gabapentin therapy, the children appeared to be symptom-free for periods ranging from 3 months to 3 years.
在加巴喷丁治疗开始之后,患儿表现出一定时间内的症状消失,其时间可达3个月至3年不等。
For one child, the parents requested that treatment be halted, despite excellent symptom control, because of involuntary eye movements that arose with use of the drug. The symptoms returned within one week.
其中一个儿童,尽管症状控制的非常良好但由于这种药物的使用是的该儿童的不随意眼动增加,应其父母要求停用了这种药物。一周内,该儿童的上述疾病症状又出现了。
In another child, who had been successfully treated for 2 years, discontinuation of gabapentin also led to a recurrence of symptoms. The symptoms resolved when therapy was restarted.
另外一个儿童,应用该种药物成功地控制了疾病达两年之久,终止该药物的使用后同样导致了患者疾病症状的复发。而一旦重新应用这种药物后,这些症状再次消失。
For such children, Hauer concluded, the findings "suggest a trial of gabapentin when there is no identifiable source of pain despite comprehensive evaluation and management."
对这类患者,Hauer给出的结论是,该项发现提示除外进行综合性评价和治疗外应该在没有可识别的疼痛源时进行有关加巴喷丁的试验。
SOURCE: Pediatrics, February 2007.
资料来源:《儿科学杂志》 2007年2月
编译如下:路透社健康专栏 2007-2-22 星期四 作者:大卫.道格拉斯
纽约(路透社健康专栏)— 研究人员在《儿科学杂志》报道,在某些有特定神经功能缺损的儿童身上应用抗癫痫药加巴喷丁可能会改善其易激惹的状态。易激惹状态或许表现了神经系统效能好传递的异常。研究领导者,Julie M. Hauer博士告诉路透社健康专栏,“目前的研究表明胃肠道的疼痛是一种颇似有神经缺损的儿童的慢性易激惹信号源。”Hauer目前在波士顿儿童医院工作,他与同事研究后指出,神经学上有缺陷的儿童较正常儿童有更高的发生慢性疼痛和易激惹的发病率,而且尽管经过彻底的检查与治疗可能的疼痛根源后这种状况仍会持续。患儿家长通常认为胃肠道是这些儿童疼痛发生的根源。研究者整理了涉及九个曾经接受过加巴喷丁用于治疗分裂性易激惹疾病的儿童的病例总综述。这些儿童中没有人能说话或步行并且他们经常一天哭泣至少一个小时甚至更长。在加巴喷丁治疗开始之后,患儿表现出一定时间内的症状消失,其时间可达3个月至3年不等。其中一个儿童,尽管症状控制的非常良好但由于这种药物的使用是的该儿童的不随意眼动增加,应其父母要求停用了这种药物。一周内,该儿童的上述疾病症状又出现了。另外一个儿童,应用该种药物成功地控制了疾病达两年之久,终止该药物的使用后同样导致了患者疾病症状的复发。而一旦重新应用这种药物后,这些症状再次消失。对这类患者,Hauer给出的结论是,该项发现提示除外进行综合性评价和治疗外应该在没有可识别的疼痛源时进行有关加巴喷丁的试验。
资料来源:《儿科学杂志》 2007年2月
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