Steroid Nasal Sprays Relieve Sinusitis Symptoms, Review Finds
Main Category: Ear, Nose and Throat News
Article Date: 23 Apr 2007 - 0:00 PDT
Every year, nearly 37 million Americans suffer from the sinus pressure, nasal congestion, cough and postnasal drip that accompany sinusitis.
Doctors often prescribe antibiotics to relieve acute sinusitis, which can develop following a chest cold. However, steroid nasal sprays either alone or with antibiotic therapy may better ease symptoms and speed recovery, suggests a new review by Israeli researchers.
Sinusitis is an inflammation of the mucous membranes that line the sinus cavities. Steroid sprays like Flonase, Nasonex and Rhinocort, which work by reducing inflammation to promote drainage in the sinuses, are often prescribed to treat chronic sinusitis and allergies symptoms.
But the use of steroids sprays for acute sinusitis is not as universally accepted.
In this review, Anca Zalmanovici, a family physician at Rabin Medical Center in Petach Tikva, and her co-author analyzed data from four randomized controlled trials including nearly 2,000 participants, all with clinical symptoms of acute sinusitis.
The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates research in all aspects of health care. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing trials on a topic.
Two of the studies evaluated patients at treatment centers in the United States, one took place in Turkey and the other included 71 medical centers in 14 countries.
Study participants, who underwent X-rays or nasal endoscopy to confirm diagnosis, received either a placebo or intranasal corticosteroids for two or three weeks, alone or in combination with antibiotics. Intranasal corticosteroids used included fluticasone propionate (Flonase), mometasone furoate (Nasonex) and budesonide (Rhinocort).
Overall, 73 percent of the patients treated with nasal steroids experienced relief or marked improvement of symptoms during the study period, compared with only 66.4 percent of patients who received the placebo.
"For every 100 patients treated with intranasal corticosteroids, seven additional patients had complete or marked symptom relief," compared to those in the placebo group, the reviewers found.
Researchers pooled data from three of the four studies, excluding the lowest-quality study from the statistical analysis.
None of the studies reported serious side effects, and rates of sinusitis relapse were similar between the treatment and placebo groups.
Stronger doses of nasal steroids appeared to work better. Patients receiving daily doses of 400 micrograms were more likely to experience relief of sinusitis symptoms, than were patients receiving 200-microgram doses.
Although there is not enough evidence to suggest that nasal steroids can stand alone for acute sinusitis treatment, "the results of these studies and reviews support the current clinical rationale of adding an intranasal corticosteroid to antibiotic therapy," reviewers say.
Allen Seiden, M.D., director of the University of Cincinnati Taste and Smell Center, said that more data are required before routine recommendations on intranasal corticosteroids can be made.
Steroid Nasal Sprays Relieve Sinusitis Symptoms, Review Finds
综述回顾分析发现：类固醇鼻腔喷雾剂能缓解鼻窦炎症状
Main Category: Ear, Nose and Throat News
主要类别：耳鼻咽喉新闻
Article Date: 23 Apr 2007 - 0:00 PDT
文章出版日期：2007年4月23日0：00
Every year, nearly 37 million Americans suffer from the sinus pressure, nasal congestion, cough and postnasal drip that accompany sinusitis.
每年有近三千七百万美国人饱受鼻窦压迫、鼻腔阻塞、咳嗽和后鼻滴涕之苦，这些症状均是伴随着鼻窦炎而来。
Doctors often prescribe antibiotics to relieve acute sinusitis, which can develop following a chest cold. However, steroid nasal sprays either alone or with antibiotic therapy may better ease symptoms and speed recovery, suggests a new review by Israeli researchers.
因为急性鼻窦炎可以发展成为支气管炎，所以医生经常开抗生素处方药来缓解急性鼻窦炎。然而，以色列共和国的研究人员的最新综述回顾研究表明：类固醇鼻腔喷雾剂单独或联合抗生素治疗能更好地缓解鼻窦炎症状并能加速康复。
Sinusitis is an inflammation of the mucous membranes that line the sinus cavities. Steroid sprays like Flonase, Nasonex and Rhinocort, which work by reducing inflammation to promote drainage in the sinuses, are often prescribed to treat chronic sinusitis and allergies symptoms.
鼻窦炎是鼻腔黏膜的炎症。像丙酸氟替卡松、内舒拿和雷诺考特这样的类固醇鼻腔喷雾剂通过减轻鼻腔黏膜的炎症来促进鼻窦的引流。这类皮质类固醇鼻腔喷雾剂通常是治疗慢性鼻窦炎和变态反应症状的处方药。
But the use of steroids sprays for acute sinusitis is not as universally accepted.
但是用类固醇鼻腔喷雾剂治疗急性鼻窦炎的观点尚未被普遍接受。
In this review, Anca Zalmanovici, a family physician at Rabin Medical Center in Petach Tikva, and her co-author analyzed data from four randomized controlled trials including nearly 2,000 participants, all with clinical symptoms of acute sinusitis.
Anca Zalmanovici是在Petach Tikva的 Rabin 医学中心的一名家庭医生，她和她的合著者在这篇综述里分析了来自两千名参与者的四个随机对照组研究资料，这些患者均有急性鼻窦炎的临床症状。
The review appears in the current issue of The Cochrane Library, a publication of The Cochrane Collaboration, an international organization that evaluates research in all aspects of health care. Systematic reviews draw evidence-based conclusions about medical practice after considering both the content and quality of existing trials on a topic.
Cochrane共同研究体是一个国际性的评价卫生保健各个方面的研究的组织。《Cochrane图书馆》是Cochrane共同研究体的出版物之一。
这篇综述就发表在《Cochrane图书馆》的现期杂志上。
Two of the studies evaluated patients at treatment centers in the United States, one took place in Turkey and the other included 71 medical centers in 14 countries.
研究的两个项目对美国治疗中心的患者进行了评价。一个项目在土耳其举行，另一个项目包括十四个国家的七十一个医学中心。
Study participants, who underwent X-rays or nasal endoscopy to confirm diagnosis, received either a placebo or intranasal corticosteroids for two or three weeks, alone or in combination with antibiotics. Intranasal corticosteroids used included fluticasone propionate (Flonase), mometasone furoate (Nasonex) and budesonide (Rhinocort).
研究参与者通过X线拍片或鼻内镜检查来确诊。分别接受安慰剂或鼻内皮质激素或鼻内皮质激素联合抗生素治疗两或三周。使用的鼻内皮质激素包括：氟替卡松丙酸酯（丙酸氟替卡松）、莫米松糠酸酯（内舒拿）和布地奈德（雷诺拷特）。
Overall, 73 percent of the patients treated with nasal steroids experienced relief or marked improvement of symptoms during the study period, compared with only 66.4 percent of patients who received the placebo.
在研究期间，接受安慰剂治疗的患者仅有百分之六十六点四的患者症状得到缓解，与之相比接受鼻腔皮质类固醇治疗的全部患者有百分之七十三的患者症状的到减轻或者症状得到显著改善。
"For every 100 patients treated with intranasal corticosteroids, seven additional patients had complete or marked symptom relief," compared to those in the placebo group, the reviewers found.
评论家比较这些研究对照组发现：“每一百名接受鼻内皮质类固醇治疗的患者中，就额外又多出七名患者的症状得到显著减轻或完全缓解。”
Researchers pooled data from three of the four studies, excluding the lowest-quality study from the statistical analysis.
研究人员将四项研究中的三项的研究资料集合起来，并剔除了统计学分析中质量最低的一项研究。
None of the studies reported serious side effects, and rates of sinusitis relapse were similar between the treatment and placebo groups.
这些研究均没有报道严重的副作用，并且鼻窦炎的复发率与安慰剂治疗组相类似。
Stronger doses of nasal steroids appeared to work better. Patients receiving daily doses of 400 micrograms were more likely to experience relief of sinusitis symptoms, than were patients receiving 200-microgram doses.
更大剂量的鼻腔类固醇治疗表现出更好的疗效。每日接受四百毫克剂量治疗的患者与每日接受两百毫克剂量治疗的患者相比较，其鼻窦炎症状似乎得到更好地缓解。
Although there is not enough evidence to suggest that nasal steroids can stand alone for acute sinusitis treatment, "the results of these studies and reviews support the current clinical rationale of adding an intranasal corticosteroid to antibiotic therapy," reviewers say.
该综述说道：“虽然目前还没有足够的证据表明鼻腔类固醇能单独应用来治疗急性鼻窦炎。这些研究和综述的结果支持目前临床合理抗生素联合使用鼻内皮质类固醇的治疗方案。”
Allen Seiden, M.D., director of the University of Cincinnati Taste and Smell Center, said that more data are required before routine recommendations on intranasal corticosteroids can be made.
Allen Seiden是Cincinnati大学味觉和嗅觉中心的主任，他说：制定鼻内皮质类固醇规范的推荐剂量使用还需要更多的资料。
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（1035字）
综述回顾分析发现：类固醇鼻腔喷雾剂能缓解鼻窦炎症状
主要类别：耳鼻咽喉新闻
文章出版日期：2007年4月23日0：00
每年有近三千七百万美国人饱受鼻窦压迫、鼻腔阻塞、咳嗽和后鼻滴涕之苦，这些症状均是伴随着鼻窦炎而来。
因为急性鼻窦炎可以发展成为支气管炎，所以医生经常开抗生素处方药来缓解急性鼻窦炎。然而，以色列共和国的研究人员的最新综述回顾研究表明：类固醇鼻腔喷雾剂单独或联合抗生素治疗能更好地缓解鼻窦炎症状并能加速康复。
鼻窦炎是鼻腔黏膜的炎症。像丙酸氟替卡松、内舒拿和雷诺考特这样的类固醇鼻腔喷雾剂通过减轻鼻腔黏膜的炎症来促进鼻窦的引流。这类皮质类固醇鼻腔喷雾剂通常是治疗慢性鼻窦炎和变态反应症状的处方药。
但是用类固醇鼻腔喷雾剂治疗急性鼻窦炎的观点尚未被普遍接受。
Anca Zalmanovici是在Petach Tikva的 Rabin 医学中心的一名家庭医生，她和她的合著者在这篇综述里分析了来自两千名参与者的四个随机对照组研究资料，这些患者均有急性鼻窦炎的临床症状。
Cochrane共同研究体是一个国际性的评价卫生保健各个方面的研究的组织。《Cochrane图书馆》是Cochrane共同研究体的出版物之一。
这篇综述就发表在《Cochrane图书馆》的现期杂志上。
研究的两个项目对美国治疗中心的患者进行了评价。一个项目在土耳其举行，另一个项目包括十四个国家的七十一个医学中心。
研究参与者通过X线拍片或鼻内镜检查来确诊。分别接受安慰剂或鼻内皮质激素或鼻内皮质激素联合抗生素治疗两或三周。使用的鼻内皮质激素包括：氟替卡松丙酸酯（丙酸氟替卡松）、莫米松糠酸酯（内舒拿）和布地奈德（雷诺拷特）。
在研究期间，接受安慰剂治疗的患者仅有百分之六十六点四的患者症状得到缓解，与之相比接受鼻腔皮质类固醇治疗的全部患者有百分之七十三的患者症状的到减轻或者症状得到显著改善。
评论家比较这些研究对照组发现：“每一百名接受鼻内皮质类固醇治疗的患者中，就额外又多出七名患者的症状得到显著减轻或完全缓解。”
研究人员将四项研究中的三项的研究资料集合起来，并剔除了统计学分析中质量最低的一项研究。
这些研究均没有报道严重的副作用，并且鼻窦炎的复发率与安慰剂治疗组相类似。
更大剂量的鼻腔类固醇治疗表现出更好的疗效。每日接受四百毫克剂量治疗的患者与每日接受两百毫克剂量治疗的患者相比较，其鼻窦炎症状似乎得到更好地缓解。
该综述说道：“虽然目前还没有足够的证据表明鼻腔类固醇能单独应用来治疗急性鼻窦炎。这些研究和综述的结果支持目前临床合理抗生素联合使用鼻内皮质类固醇的治疗方案。”
Allen Seiden是Cincinnati大学味觉和嗅觉中心的主任，他说：制定鼻内皮质类固醇规范的推荐剂量使用还需要更多的资料。
Doctors often prescribe antibiotics to relieve acute sinusitis, which can develop following a chest cold.
因为急性鼻窦炎可以发展成为支气管炎，所以医生经常开抗生素处方药来缓解急性鼻窦炎。
What causes Chest Cold?
Some of the possible causes of Chest Cold include:
Often follows common cold
Chronic Obstructive Pulmonary/Airways Disease
Smokers
