初译：
Title：Radiological findings, clinical course, and outcome in asymptomatic moyamoya disease: results of multicenter survey in Japan.
一项日本的有关无症状烟雾病影像学、临床转归的多中心研究
Author：Kuroda S, Hashimoto N, Yoshimoto T, Iwasaki Y;
Resource: Stroke. 2007 May;38(5):1430-5. Epub 2007 Mar 29.
Abstract：摘要：
BACKGROUND AND PURPOSE: Although the development of a noninvasive MR examination has increased the opportunity to identify asymptomatic patients with moyamoya disease who have experienced no stroke episodes, their clinical features are still unclear. This was the first multicenter, nation-wide survey focused on asymptomatic moyamoya disease in Japan and was designed to clarify their clinical features.
背景和目的：尽管无创性磁共振检查的发展增加了鉴别出无症状患者既往无卒中发作的烟雾病，但这些患者的临床特征仍不清楚。这是第一个日本多中心的，全国性的关于无症状性烟雾病的调查，以期阐明此病的临床特征。
METHODS: A clinical database of asymptomatic patients with moyamoya disease was collected from 12 participating hospitals in Japan between 2003 and 2006. In total, 40 patients were enrolled in this historical prospective cohort study. Of these, 6 underwent surgical revascularization, including superficial temporal artery to middle cerebral artery anastomosis and/or pial synangiosis. Their demographic and radiological findings as well as outcome were evaluated.
方法：在日本2003至2006年间收集来自12个医院无症状烟雾病患者的临床资料。在这项历史前瞻性队列研究中纳入40例病例。其中，6例行外科血管成形术，包括浅表颞动脉到中脑动脉吻合和或颈部吻合。然后对他们的放射学结果进行统计评估。
RESULTS: On initial evaluation, cerebral infarction and disturbed cerebral hemodynamics were detected in approximately 20% and 40% of the involved hemispheres, respectively. Angiographical stage was more advanced in more elderly patients. Of 34 nonsurgically treated patients, 7 experienced transient ischemic attack (n=3), ischemic stroke (n=1), or intracranial bleeding (n=3) during follow-up periods (mean, 43.7 months). The annual risk for any stroke was 3.2%. Disease progression was associated with ischemic events or silent infarction in 4 of 5 patients. No cerebrovascular event occurred in the 6 patients who underwent surgical revascularization.
结果：在初次评估中，有关脑半球区域可检测到脑梗塞和大脑血流动力学紊乱分别约为20％和40%。在更老年性患者中，血管造影影像的分期更晚。在34例非手术治疗的患者中，7例在随访时期（平均为43.7个月）存在短暂性缺血发作(n=3)，缺血性中风（n=1)，或颅内出血(n=3)。任何卒中的年风险率为3.2％。在5例患者中4例疾病进展和缺血事件或静息梗塞形成相关。而6例行血管成形术患者中无一例发生脑血管事件。
CONCLUSIONS: The findings revealed that asymptomatic moyamoya disease is not a silent disorder and may potentially cause ischemic or hemorrhagic stroke. Asymptomatic patients with moyamoya disease should be carefully followed-up to further clarify their outcome and to establish the management guideline for them.
结论：这个发现揭示了无症状性烟雾病并非是一种静息性的病症，其可能潜在地引起缺血性或出血性卒中发生。无症状烟雾病患者需远期详细随访阐明结果从而建立治疗指南。
PMID: 17395863
编译投稿：（516字）
【据《卒中》杂志2007年5月】最新一期研究报道题为：无症状烟雾病影像学、临床转归的多中心研究
研究背景认为，尽管无创性磁共振检查的发展增加了鉴别出无症状患者既往无卒中发作的烟雾病，但这些患者的临床特征仍不清楚。在此项研究中，其是第一次进行多中心的，全国性的关于无症状性烟雾病的调查，以期阐明此病的临床特征。研究中从2003至2006年间，收集日本12个医院无症状烟雾病患者的临床资料。在这项历史前瞻性队列研究中纳入40例病例。其中，6例行外科血管成形术，包括浅表颞动脉到中脑动脉吻合和或颈部吻合。然后对他们的放射学结果进行统计评估。结果显示，在初次评估中，有关脑半球区域可检测到脑梗塞和大脑血流动力学紊乱分别约为20％和40%。在更老年性患者中，血管造影影像的分期更晚。在34例非手术治疗的患者中，7例在随访时期（平均为43.7个月）存在短暂性缺血发作(n=3)，缺血性中风（n=1)，或颅内出血(n=3)。任何卒中的年风险率为3.2％。在5例患者中4例疾病进展和缺血事件或静息梗塞形成相关。而6例行血管成形术患者中无一例发生脑血管事件。由此研究人员提出结论，无症状性烟雾病并非是一种静息性的病症，其可能潜在地引起缺血性或出血性卒中发生。无症状烟雾病患者需远期详细随访阐明结果从而建立治疗指南。
