第二篇
Kidney International (2007) 71, 679–686.
Long-term outcome of acute tubular necrosis: A contribution to its natural history
F Liaño1,2, C Felipe1, M T Tenorio1, M Rivera1, V Abraira3, J M Sáez-de-Urturi4, J Ocaña1, C Fuentes5 and S Severiano5
Abstract
As long-term outcome studies of acute renal failure (ARF) are scarce and non-homogeneous, we studied 187 consecutive acute tubular necrosis (ATN) patients without previous nephropathies, discharged alive from our hospital between October 77 and December 92 and followed-up until December 99 (range 7–22 years; median 7.2). Variables were analyzed at the time of the acute episode and during follow-up. In 2000–2001 a clinical evaluation was made in 58 of the 82 patients still alive. Ten patients were lost to follow-up and 95 died. In 59% death was related with the disease present when the ATN developed. Kaplan–Meir survival curve showed 89, 67, 50, and 40% at 1, 5, 10, and 15 years, respectively, after discharge. Survival curves were significantly better (log-rank P<0.001) among the youngest, those surviving a polytrauma, those without comorbidity and surprisingly those treated in intensive care units. The proportional Cox model showed that age (hazard ratio (HR) 1.04 per year of age; P=0.000), presence of comorbid factors (HR 4.29; P=0.006), surgical admission (HR 0.45; P=0.000), and male sex (HR 1.72; P=0.020) were the variables associated with long-term follow-up. In the evaluated patients renal function was normal in 81%. Long-term outcome after ARF depends on absence of co-morbid factors, cause of initial admission and age. Although the late mortality rate is high and related with the original disease, renal function is adequate in most patients.
本人已认领该文编译，48小时后若未提交译文，请其他战友自由认领。
Long-term outcome of acute tubular necrosis: A contribution to its natural history
急性肾小管坏死的长期预后:自然病史的影响
As long-term outcome studies of acute renal failure (ARF) are scarce and non-homogeneous, we studied 187 consecutive acute tubular necrosis (ATN) patients without previous nephropathies, discharged alive from our hospital between October 77 and December 92 and followed-up until December 99 (range 7–22 years; median 7.2).
因为的长期预后方面的研究是很少并且是多起因的,此次我们研究187个稳定的急性肾小管坏死的病人(并且以前没有肾病的),排除存活的从十月77个病人到十一月92个并且随访直到十一月99个(范围是7--22年,平均7.2)
Variables were analyzed at the time of the acute episode and during follow-up.
研究急性发作期和随访中的各种变化.
In 2000–2001 a clinical evaluation was made in 58 of the 82 patients still alive.
在2000---2001年,对存活的82个病人中的58做了一个临床评价.
Ten patients were lost to follow-up and 95 died. In 59% death was related with the disease present when the ATN developed.
十个病人失访,95个死亡.其中59%的死亡和病人急性肾小管坏死发展有关.
Kaplan–Meir survival curve showed 89, 67, 50, and 40% at 1, 5, 10, and 15 years, respectively, after discharge.
卡普兰梅厄生存曲线显示89, 67, 50, and 40% at 1, 5, 10, and 15 年是有显著差异的
Survival curves were significantly better (log-rank P<0.001) among the youngest, those surviving a polytrauma, those without comorbidity and surprisingly those treated in intensive care units.
在年轻的,多发性损失后的,和那些没有相同病但他们住在重症监护室的病人,生存曲线是有明显不同(等级P<0.001)
The proportional Cox model showed that age (hazard ratio (HR) 1.04 per year of age; P=0.000), presence of comorbid factors (HR 4.29; P=0.006), surgical admission (HR 0.45; P=0.000), and male sex (HR 1.72; P=0.020) were the variables associated with long-term follow-up.
Cox 比例风险模型显示:年龄(风险比1.04每年/年龄; P=0.000),同时存在的其他疾病因素(风险比 4.29; P=0.006),外科因素(风险比 0.45; P=0.000),性别(男性风险比 1.72; P=0.020)是伴随长期随访变化的.
In the evaluated patients renal function was normal in 81%. Long-term outcome after ARF depends on absence of co-morbid factors, cause of initial admission and age. Although the late mortality rate is high and related with the original disease, renal function is adequate in most patients.
这些病人的肾功能是正常的在81%.急性肾小管坏死的长期预后取决于是否同时存在着其它疾病因素,病因和年龄.虽然远期死亡率很高也和最初疾病相关,但大多数病人的肾功能是可以的.
谢谢楼上战友的翻译，但是由于本人的愚拙，看后还是摸不着头脑，希望本人的修改意见能够有所帮助。
As long-term outcome studies of acute renal failure (ARF) are scarce and non-homogeneous, we studied 187 consecutive acute tubular necrosis (ATN) patients without previous nephropathies, discharged alive from our hospital between October 77 and December 92 and followed-up until December 99 (range 7–22 years; median 7.2).
因为关于急性肾衰（ARF）长期预后的研究很少而且结论不一，我们观察了本院从十月份（77例）到十二月份（92例）存活出院并一直随访到次年十二月份（99例）共187例没有既往肾脏病史的急性肾小管坏死患者（年龄范围7–22岁，中位数7.2年）。
Kaplan–Meir survival curve showed 89, 67, 50, and 40% at 1, 5, 10, and 15 years, respectively, after discharge。
Kaplan–Meir生存曲线显示在出院后5、10和15年后其存活率分别为89%, 67%, 50%和 40%。
Survival curves were significantly better (log-rank P<0.001) among the youngest, those surviving a polytrauma, those without comorbidity and surprisingly those treated in intensive care units.
年轻患者、经历多发性损伤而存活下来，没有伴随疾病以及出乎意料的在ICU处理过的患者其生存曲线显著占优(对数秩P<0.001)。
The proportional Cox model showed that age (hazard ratio (HR) 1.04 per year of age; P=0.000), presence of comorbid factors (HR 4.29; P=0.006), surgical admission (HR 0.45; P=0.000), and male sex (HR 1.72; P=0.020) were the variables associated with long-term follow-up.
Cox 比例风险模型显示：年龄[风险比1.04/年龄(岁); P=0.000]，有无伴随疾病（(风险比 4.29; P=0.006）、因外科原因住院（风险比0.45; P=0.000）和男性（风险比1.72; P=0.020）是与长期随访结果有关的变量。
In the evaluated patients renal function was normal in 81%. Long-term outcome after ARF depends on absence of co-morbid factors, cause of initial admission and age. Although the late mortality rate is high and related with the original disease, renal function is adequate in most patients
81%被分析的患者肾功能正常。急性肾衰后的长期转归取决于没有伴随疾病、第一次住院时的病因和年龄。尽管后期死亡率比较高并且和原发病有关，但多数患者肾功能尚可。
谢谢指正!
