Title：Intrahepatic detection of FOXP3 gene expression after liver transplantation using minimally invasive aspiration biopsy.
标题：肝移植后使用微创针吸活检术监测肝内FOXP3基因表达
Author: Demirkiran A, Baan CC, Kok A, Metselaar HJ, Tilanus HW, van der Laan LJ.
作者：Demirkiran A, Baan CC, Kok A, Metselaar HJ, Tilanus HW, van der Laan LJ.
Source:Transplantation. 2007 Mar 27; 83:819-23.
来源： 移植。2007年3月27日；83期第6卷，819-823页。
IF:3.879(2005)
影响因子：3.879(2005)
Intragraft accumulation of Forkhead box P3 (FOXP3)-positive regulatory T cells (Treg) is associated with local suppression of alloresponses in transplantation models.
移植器官内FOXP3阳性调节T细胞（Treg）聚集与移植模型中异体反应局部抑制有关。
In the current study, the utility of the minimally invasive fine needle aspiration biopsy for the intragraft detection of FOXP3 and interferon (IFN)-gamma mRNA expression was investigated in clinical liver transplantation (LTx).
最近的研究中，临床肝移植中开展了以微创细针抽吸活检监测肝内FOXP3基因和干扰素-γ（IFN-γ）mRNA表达的调查。
Intragraft FOXP3 increased within the first year after LTx, but not in blood. Elevated FOXP3, but not IFN-gamma expression, in the liver was observed after hepatitis C virus (HCV) reinfection and after a previous episode of acute rejection.
肝内而非血内FOXP3在肝移植后一年内表达增强。在丙肝病毒（HCV）再次感染和先前的急性排斥后均可观察到肝内表达增强的FOXP3，而并非IFN-γ。
These data show the feasibility of aspiration biopsy for intragraft monitoring of gene expression.
这些资料表明针吸活检术监测基因表达是可行的。
Intrahepatic FOXP3 levels are associated with HCV reinfection, a history of acute rejection, and increased within the first year after LTx.
肝内FOXP3水平与HCV再感染和急性排斥史有关，且在肝移植后第一年升高。
Differences in gene expression between the graft and blood underline the importance of local immune monitoring.
移植器官和血液基因表达的差异彰显出局部免疫监测的重要性。
编译：
肝移植后使用微创针吸活检可监测肝内FOXP3基因表达
Demirkiran A等在《移植》杂志2007年83期第6卷发表的文章认为，肝移植后使用微创针吸活检可监测肝内FOXP3基因表达。（Transplantation. 2007 Mar 27; 83:819-23.）
移植器官内FOXP3阳性调节T细胞（Treg）聚集与移植模型中异体反应局部抑制有关。近期临床肝移植中开展了以微创细针抽吸活检监测肝内FOXP3基因和干扰素-γ（IFN-γ）mRNA表达的研究。研究发现肝内FOXP3在肝移植后一年内表达增强，而血内无变化。在丙肝病毒（HCV）再次感染和先前的急性排斥后均可观察到肝内表达增强的FOXP3，而并非IFN-γ。这表明针吸活检术监测肝内基因表达是可行的。Demirkiran A等认为，移植的器官和血液基因表达上存在差异突出显示了局部免疫监测重要性。
