Author:B-M. Larsson
Abstract:
Keywords: Asthma, body mass index, childhood, lung function, menarche, sex
Received: June 20, 2006
Accepted December 21, 2006
Few data exist on associations between childhood adiposity and incident asthma in later life. The present authors examined the relationship between childhood body mass index (BMI) and incident asthma beginning in adolescence or in adult life.
All subjects included in the study were participants in the Tasmanian Asthma Survey, a large population-based cohort study, and were asthma free at 7 yrs of age. Weight, height and lung function were measured at 7 yrs of age. Asthma status at 7 and 32 yrs of age was ascertained by questionnaire. Odds ratios were calculated for the association between childhood adiposity, expressed as "overweight" or as BMI z-score quartiles at 7 yrs of age, and asthma development after that age.
In females, but not in males, there was a significant association between adiposity at 7 yrs of age and current asthma at 32 yrs of age that developed after the age of 21 yrs. The association was not explained by childhood lung function or age at menarche. There was no association between adiposity at 7 yrs of age and asthma that developed after that age and remitted at 32 yrs of age in either sex.
Higher body mass index in nonasthmatic young females at 7 yrs of age predicts risk of current asthma developing in adult life.
Eur Respir J 2007; 29:668-675
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Title:Childhood adiposity predicts adult-onset current asthma in females: a 25-yr prospective study
标题：儿童肥胖症预测成人女性发病的哮喘：一项25年的前瞻性研究
儿童肥胖症预测女性哮喘的成人期发作：一项25年的前瞻性研究
Author:B-M. Larsson
作者：B-M. Larsson
Abstract:
摘要：
Keywords: Asthma, body mass index, childhood, lung function, menarche, sex
关键词：哮喘，体重指数，儿童期，肺功能，月经初潮，性别
Received: June 20, 2006
Accepted December 21, 2006
收稿日期：2006.7.20
接受日期：2006.12.21
Few data exist on associations between childhood adiposity and incident asthma in later life. The present authors examined the relationship between childhood body mass index (BMI) and incident asthma beginning in adolescence or in adult life.
很少数据显示儿童期肥胖和之后生活中的哮喘发病有关。首席作者调查了儿童期体重指数(BMI)和青春期或成年期哮喘发病间的关系。
All subjects included in the study were participants in the Tasmanian Asthma Survey, a large population-based cohort study, and were asthma free at 7 yrs of age. Weight, height and lung function were measured at 7 yrs of age. Asthma status at 7 and 32 yrs of age was ascertained by questionnaire. Odds ratios were calculated for the association between childhood adiposity, expressed as "overweight" or as BMI z-score quartiles at 7 yrs of age, and asthma development after that age.
研究纳入的所有受试者都参加了一项大规模的以人群为基础的群组研究¬¬¬－塔斯梅尼亚哮喘研究，而且这些受试者在7岁时都没有哮喘。对7岁时的体重，身高和肺功能进行测量。通过问卷调查明确7岁和32岁的哮喘状态。计算以7岁时“超重”或BMI总得分的四分位数为表现的儿童期肥胖和之后出现哮喘间关系的优势比。
In females, but not in males, there was a significant association between adiposity at 7 yrs of age and current asthma at 32 yrs of age that developed after the age of 21 yrs. The association was not explained by childhood lung function or age at menarche. There was no association between adiposity at 7 yrs of age and asthma that developed after that age and remitted at 32 yrs of age in either sex.
对于女性，在其7岁肥胖和21岁以后逐渐产生及到32岁哮喘发病间有明显联系，但男性中未见此情况。这种关系不能用儿童期肺功能或月经初潮年龄来解释。在男女中都未见7岁时肥胖和之后逐渐产生哮喘并在32岁减轻间有联系。
Higher body mass index in nonasthmatic young females at 7 yrs of age predicts risk of current asthma developing in adult life.
7岁无哮喘女孩子的较高体重指数预示其成年期的哮喘发作风险。
Eur Respir J 2007; 29:668-675
《欧洲呼吸杂志》2007; 29:668-675
PS:蓝色标记部分，不是是否翻译正确，remitted当作何解？请高手指点。
编译：
很少数据显示儿童期肥胖和之后生活中哮喘发病有关。B-M. Larsson进行了一项25年的前瞻性研究，对儿童期体重指数(BMI)和青春期或成年期哮喘发病间的关系进行了调查。（Eur Respir J 2007; 29:668-675）
研究纳入的所有受试者都参加了一项大规模的以人群为基础的群组研究¬¬¬－塔斯梅尼亚哮喘研究，而且这些受试者在7岁时都没有哮喘。对7岁时的体重、身高和肺功能进行测量。通过问卷调查明确7岁和32岁的哮喘状态。计算以7岁时“超重”或BMI总得分的四分位数为表现的儿童期肥胖和之后出现哮喘间关系的优势比。
结果发现，对于女性，在其7岁肥胖和21岁以后逐渐产生及到32岁哮喘发病间有明显联系，但男性中未见此情况。这种关系不能用儿童期肺功能或月经初潮年龄来解释。在男女中都未见7岁时肥胖和之后逐渐产生哮喘并在32岁减轻间有联系。因此得出结论，7岁无哮喘女孩子的较高体重指数预示其成年期的哮喘发作风险。（丁香）
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