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λã ҽѧ  > ִҵҩʦ > ִҵҩʦԾ >
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ִҵҩʦҩѧܣйʽ⣡Щ

2019-06-25 17:40 ҽѧ
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йִҵҩʦϰд󲿷ֿΪѵIJ־ҩѧ㣡ݴˣСݣйʽ⣡Щ

ִҵҩʦҩѧܣйʽ⣡Щ

˥

ʾҩĿл졢йҩt1/2Слйҩ t1/2

ʽt1/2=0.693/k

ijҩһʹٶȳK=0.095h-1ҩ˥t1/2Ϊ

A.8.0h

B.7.3h

C.5.5h

D.4.0h

E.3.7h

𰸣B

t1/2=0.693/kֱӴֵ㣬t1/2=0.693/0.095h-1=7.3h.

۷ֲݻ

ҩѪҩŨȼ໥ϵһ“V” ʾΪڵҩﰴѪŨȷֲʱҪҺݻ

ʽV=X/C

ʽУX ΪҩV DZ۷ֲݻC ѪҩŨȡ

עijҩX0=60mgʼѪҩŨΪ15μg/ml۷ֲݻVǣ

A.0.25L

B.2.5L

C.4L

D.15L

E.40L

𰸣C

V=X/CֱӴֵ㣬V=60/15=4L.

̬ѪҩŨ

ʱѪҩŨһ㶨ˮƽҩٶȵҩٶȡ Cssʾ

ʽCss=k0/kV

ɼ

ھע֮ѪҩŨȾ̬ŨȵIJܴҩİ˥0.5Сʱմ̬95%Ҫ2.16СʱϡΪˣڵעʼʱҪעһɼʹѪҩŨѸٴﵽӽ Css֮ԾעάָŨȡɼΪ׼

ʽX0=CssV

ע/̹1.251.0g̹0.25g˾ϵģֱ͡۷ֲݻV=0.5L/Kg.60KgôҩкϵͳȾƣϣ/̹ɴﵽ0.1g/L/̹ĸɼΪA.1.25g1ƿ

B.2.5g2ƿ

C.3.75g3ƿ

D.5.0g4ƿ

E.6.25g5ƿ

𰸣C

ɼ

X0=CssV=0.1g/L×0.5L/Kg×60Kg=3.0g.

3×1.25=3.75g.

ö

ָҩﱻսѪҺѭٶ̶ȡѪҩŨȷöоõķ߷ֱƼαƼ󣬲ⶨѪҩŨȣöȡҲƼT αƼRѪҩŨ-ʱµıʳöȡαƼǾעʱõıʳƾöȣעҩҩȫѪҺѭ

öȣ

ʽF=AUCT/AUCR×100%

öȣ

ʽF=AUCT/AUCiv×100%

ɳǽöоþעڷҩʽҩΪ400mgעͿڷҩAUCֱΪ40ug.h/ml36ug.h/ml.Ϣɳöȼȷ

A.öΪ55%

B.öΪ55%

C.öΪ90%

D.öΪ90%

E.öΪ50%

𰸣D

αƼǾעʱõıʳƾöȣעҩҩȫѪҺѭö36/40×100%=90%

ǵλʱͿĺҩѪֳΪʣʳ“Cl”ʾClDZʾѪҺѪҩʻЧʵҩѧλ“/ʱ”ʾҪҩĿ

ʽCl=kV

ijҩ˥6.93h۷ֲݻ100Lҩнǿ׹ЧӦδлййռ20%.עҩ200mgAUC20μg.h/mlƱƬڿڷҩ1000mgAUCΪ10μg.h/ml.ҩĸʣ

A.2L/h

B.6.93L/h

C.8L/h

D.10L/h

E.55.4L/h

𰸣C

t1/2=0.693/kó k=0.1 Cl=kV=0.1×100=10L/hҩнǿ׹ЧӦδлййռ20%.ʸռ80%.

=10×80%=8L/h.

ҩƷ

ҩƷʶļλʾϣҪɽлλ5λ3

λ弶 ǧˣkgˣgˣmg΢ˣμgɿˣng
λ Lml΢μl

λ

1.ڷҩǰ˽̻Ỽμ

1

ùسܽ1οڷ0.25g0.5gʶÿĹ250mg.

֮Ĺϵ㼴250mg=0.25g500mg=0.5g˿ɷ1Ƭ2Ƭ

2

άB12עÿμע50200μgÿ֧ʶΪ0.1mg.

ݻ㼴0.1mg=100μg˿ɸ0.050.2mgע1/2-2֧

2.ҩijһֵ

1

1500mlˮкNa+ٿˣ

1500mlˮкȻƵ=0.9%×1500=13.5g

ȻƵķ=58.45

Ƶķ=23

Na+ĺ=13.5g×23/58.45=5.31g

2

ٺ˵ؾʯȥ1mgȥ൱

ȥط169.18ؾʯȥط337.28ؾʯȥص=1mg×337.28/169.18=2mg

ٷֱŨȼ

ٷŨȣϵָ100gҺʵĿԷ%ggʾ

ٷŨ=gҺg×100%

ٷŨȣϵָ100mlҺʵĿԷ%gmlʾ

ٷŨ=gҺml×100%

ٷŨȣϵָ100mlҺҺĺԷ%mlmlʾ

ٷŨ=mlҺml×100%

ŨŨϡ

ʽCŨ×VŨ = Cϡ×Vϡ

70%Ҵ1000ml95%ҴӦƣ

95%Ҵ=70%×1000/95%=736.8ml

70%Ҵ1000mlȡ95%Ҵ736.8mlˮϡ1000ml.

ע2008-2010п

ŨȻ͵Ļ

Ӧý淨㣨ԣ

10%עҺ1000mlֽ50%5%ŨȵעҺƣ

裺50%עҺXml5%עҺ1000Xmlùʽ50%X+ 5% x1000X=10%×1000ãX=111ml 1000-111m1=889ml10%עҺ1000mlȡ50%עҺ111ml5%עҺ889ml.

Ũȵļ

Ѫ͸ŨΪ298mmol/L

͸Ũ280310mmol/LΪҺ

͸ŨС280mmol/LΪҺҩȦ

͸Ũȴ310mmol/LΪҺ

㽵ݷ

һ£ѪҺıֵΪ-0.52棬ѧԭκҺ㽵-0.52棬ѪҺ

ijҩ1%Һı½ֵ֪ʱøҩҺƵҺҩɰʽ㣺

ʽW = 0.52×V/100×b

УVΪƵҺbΪҩ1%½ֵWΪҩ

ijҩҺǵʱҪҩΪɰʽ㣺

ʽW=0.52-b×c×V100×b'

УWΪӵҩbΪҩ1%½ֵCΪҩٷŨȣVΪҺ b'Ϊҩ1%½ֵ

1%ؿעҺ100mLҺҪȻƣ

ؿbֵΪ0.1090.9%ȻҺb1ֵΪ0.578.

W=0.52-0.109×1×100/100×0.578=0.711g

ȻƵ

ָ1gҩɵȻ

ȻƵΪ0.471g0.47gȻƿɲȵ͸ѹ

õĵҺҩɰʽ

ʽW = 0.9% × V/E

УWΪƵҺҩVΪҺEΪ1gҩȻƵ

ڼʽ㣺

ʽW=0.9-C×E×V/100

WΪƵҺȻƵgVΪҺmlEΪ1gҩȻƵCΪҺҩİٷŨ

1%ؿעҺ500mLҺҪȻƣ

ؿȻƵΪ0.21

W=0.9-1×0.21×500100=3.45g.

ЧĻ

ЧۣϵָشƷЧ۵λʣЧֵ1μgΪ1IUʵλ

ùءùءùصԴ1μgΪ1IU.ijһض1μgλһΪ1IUùG0.6μgΪ1IUùG0.6329μgΪ1IUĻغ1μgΪ1IU.

ԭϺıʾָԭʵлмٵĵ׼ɵʣΪƷ

ùصЧ1mgΪ 672IU л񹲺͹ҩ䡷涨1mgЧ۲610IUԲƷЧ610-672IU֮䣬Чڱǩעڵнл㡣

άĻ

άAļӻƴREʾÿ1UάA൱RE0.344μg.

άA1U=0.3RE

άDÿ40000U=1mg.

άEӵʾάE 1U൱ڣ1mg dl-αᣬ൱0.7mg dl-αӣ൱0.8mg d-αᡣ

Ӫȼ

ӪָӪӳ⣬羲⡢Ƥ¡ǻڵ;ԾΪҪ;ʳӪسΪӪ

ӪʵɣҪΪǡ֬ᡢʡάء΢Ԫء

߼״̬ͬͬһΪ2432 kcal/kg·dӦݻߵؼӪ䷽

ǡ֬

1gṩ4kcal1g֬ṩ9kcal1gṩ4kcal

ǡ֬

a.ȵȣ

͵֮һΪ150kcal1gN

ӦʱӦӵĹɽȵȵΪ100kcal1gNлֵ֧Ҫ

b.֬ȣ

һ£70%NPCṩ30%֬ṩ

˵Ӧʱʵ֬ĹԼǵ߿ṩռ50%.

Ƽ

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