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【medical-news】慢性关节炎疼痛似乎未改变神经内分泌功能

Chronic Arthritis Pain Does Not Seem to Alter Neuroendocrine Function

NEW YORK (Reuters Health) Dec 28 - In contrast to the findings of some prior studies, neuroendocrine function is not appreciably altered in otherwise healthy men with chronic osteoarthritis (OA) pain, a new study indicates.

Prior reports of hormonal abnormalities in men with chronic pain, the researchers suggest, may have resulted from the confounding effects of comorbid illness such as depression or inflammatory disease or coexistent medication use.

As reported in the December Journal of Clinical Endocrinology and Metabolism, Dr. Suzan Khoromi and colleagues at the National Institutes of Health in Bethesda, Maryland tested the hypothesis that chronic pain activates adrenocorticotropic (ACTH) and cortisol and suppresses luteinizing hormone (LH) and testosterone.

Subjects included 16 opioid-nave men with chronic OA pain and 12 healthy, opioids- and pain-free men of similar age and weight.

The researchers failed to detect any significant between-group differences in 12-hour overnight mean or integrated concentrations of ACTH, cortisol, LH or testosterone.

"We detected significantly higher morning concentrations of LH without concomitant differences in total and free testosterone in men with OA, compared with healthy men," the team notes. This suggests "the presence of incipient, or compensated, primary hypogonadism in our OA patients."

"Further studies appear warranted to investigate 24-hour secretory patterns of LH and gonadal steroids in men and women with diverse etiologies of chronic pain," they conclude.

J Clin Endocrinol Metab 2006;91:4313-4318.

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Chronic Arthritis Pain Does Not Seem to Alter Neuroendocrine Function
慢性关节炎疼痛似乎未改变神经内分泌功能

NEW YORK (Reuters Health) Dec 28 - In contrast to the findings of some prior studies, neuroendocrine function is not appreciably altered in otherwise healthy men with chronic osteoarthritis (OA) pain, a new study indicates.
纽约(路透通讯社健康版)12月28日——一项新的研究表明,与先前的一些研究所发现的相反,对于另外那些患有慢性关节炎(OA)疼痛的健康人来说,神经内分泌功能并非略微有一点改变。

Prior reports of hormonal abnormalities in men with chronic pain, the researchers suggest, may have resulted from the confounding effects of comorbid illness such as depression or inflammatory disease or coexistent medication use.
研究人员建议,先前关于患有慢性痛的人激素异常的报道可能受到同病(例如:抑郁症或炎性疾病或者共同药物治疗的使用)的混淆影响。

As reported in the December Journal of Clinical Endocrinology and Metabolism, Dr. Suzan Khoromi and colleagues at the National Institutes of Health in Bethesda, Maryland tested the hypothesis that chronic pain activates adrenocorticotropic (ACTH) and cortisol and suppresses luteinizing hormone (LH) and testosterone.
临床内分泌与代谢杂志十二月刊报道,Suzan Khoromi教授和他Bethesda,马里兰国立卫生研究所的同事们测试了如下假设:慢性痛激活了促肾上腺皮质激素(ACTH)和氢化可的松并抑制了促黄体激素(LH)和睾酮。

Subjects included 16 opioid-nave men with chronic OA pain and 12 healthy, opioids- and pain-free men of similar age and weight.
课题研究包括16位患有慢性关节炎的阿片样药物使用者和12位相似年龄和体重的无痛健康受试者(使用类罂粟碱)。

The researchers failed to detect any significant between-group differences in 12-hour overnight mean or integrated concentrations of ACTH, cortisol, LH or testosterone.
研究人员在12小时通宵观察中检测ACTH、氢化可的松、LH、睾酮的积分浓度,并没有发现任何显著性组间差异。

"We detected significantly higher morning concentrations of LH without concomitant differences in total and free testosterone in men with OA, compared with healthy men," the team notes. This suggests "the presence of incipient, or compensated, primary hypogonadism in our OA patients."
研究小组记录:“我们检测到与健康人相比,患有慢性关节炎者清晨时有显著的高LH浓度,但没有伴随体内总睾酮和游离睾酮的差异。”这提示“我们的慢性关节炎病人身上起初或补偿性的存在原发性性腺机能减退。”

"Further studies appear warranted to investigate 24-hour secretory patterns of LH and gonadal steroids in men and women with diverse etiologies of chronic pain," they conclude.
他们还推断“未来的研究将集中在观察患有不同病因慢性痛的男性及女性体内LH和性腺甾体类24小时的分泌模式。”

译文:

慢性关节炎疼痛似乎未改变神经内分泌功能

纽约(路透通讯社健康版)12月28日——一项新的研究表明,与先前的一些研究所发现的相反,对于另外那些患有慢性关节炎(OA)疼痛的健康人来说,神经内分泌功能并非略微有一点改变。

研究人员建议,先前关于患有慢性痛的人激素异常的报道可能受到同病(例如:抑郁症或炎性疾病或者共同药物治疗的使用)的混淆影响。临床内分泌与代谢杂志十二月刊报道,Suzan Khoromi教授和他Bethesda,马里兰国立卫生研究所的同事们测试了如下假设:慢性痛激活了促肾上腺皮质激素(ACTH)和氢化可的松并抑制了促黄体激素(LH)和睾酮。课题研究包括16位患有慢性关节炎的阿片样药物使用者和12位相似年龄和体重的无痛健康受试者(使用类罂粟碱)。研究人员在12小时通宵观察中检测ACTH、氢化可的松、LH、睾酮的积分浓度,并没有发现任何显著性组间差异。研究小组记录:“我们检测到与健康人相比,患有慢性关节炎者清晨时有显著的高LH浓度,但没有伴随体内总睾酮和游离睾酮的差异。”这提示“我们的慢性关节炎病人身上起初或补偿性的存在原发性性腺机能减退。”他们还推断“未来的研究将集中在观察患有不同病因慢性痛的男性及女性体内LH和性腺甾体类24小时的分泌模式。”
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